RT Journal Article
SR Electronic
T1 Systematic mapping of chromatin state landscapes during mouse development
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 166652
DO 10.1101/166652
A1 David U. Gorkin
A1 Iros Barozzi
A1 Yanxiao Zhang
A1 Ah Young Lee
A1 Bin Li
A1 Yuan Zhao
A1 Andre Wildberg
A1 Bo Ding
A1 Bo Zhang
A1 Mengchi Wang
A1 J. Seth Strattan
A1 Jean M. Davidson
A1 Yunjiang Qiu
A1 Veena Afzal
A1 Jennifer A. Akiyama
A1 Ingrid Plajzer-Frick
A1 Catherine S. Pickle
A1 Momoe Kato
A1 Tyler H. Garvin
A1 Quan T. Pham
A1 Anne N. Harrington
A1 Brandon J. Mannion
A1 Elizabeth A. Lee
A1 Yoko Fukuda-Yuzawa
A1 Yupeng He
A1 Sebastian Preissl
A1 Sora Chee
A1 Brian A. Williams
A1 Diane Trout
A1 Henry Amrhein
A1 Hongbo Yang
A1 J. Michael Cherry
A1 Yin Shen
A1 Joseph R. Ecker
A1 Wei Wang
A1 Diane E. Dickel
A1 Axel Visel
A1 Len A. Pennacchio
A1 Bing Ren
YR 2017
UL http://biorxiv.org/content/early/2017/08/03/166652.abstract
AB Embryogenesis requires epigenetic information that allows each cell to respond appropriately to developmental cues. Histone modifications are core components of a cell’s epigenome, giving rise to chromatin states that modulate genome function. Here, we systematically profile histone modifications in a diverse panel of mouse tissues at 8 developmental stages from 10.5 days post conception until birth, performing a total of 1,128 ChIP-seq assays across 72 distinct tissue-stages. We combine these histone modification profiles into a unified set of chromatin state annotations, and track their activity across developmental time and space. Through integrative analysis we identify dynamic enhancers, reveal key transcriptional regulators, and characterize the role of chromatin-based repression in developmental gene regulation. We also leverage these data to link enhancers to putative target genes, revealing connections between coding and non-coding sequence variation in disease etiology. Our study provides a compendium of resources for biomedical researchers, and achieves the most comprehensive view of embryonic chromatin states to date.