RT Journal Article
SR Electronic
T1 Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 173062
DO 10.1101/173062
A1 Eli A Stahl
A1 Andreas J Forstner
A1 Andrew McQuillin
A1 Stephan Ripke
A1 Vassily Trubetskoy
A1 Manuel Mattheisen
A1 Weiqing Wang
A1 Yunpeng Wang
A1 Jonathan R I Coleman
A1 Héléna A Gaspar
A1 Christiaan A de Leeuw
A1 Jennifer M Whitehead Pavlides
A1 Loes M Olde Loohuis
A1 Anil P S Ori
A1 Tune H Pers
A1 Peter A Holmans
A1 Douglas M Ruderfer
A1 Phil H Lee
A1 Alexander W Charney
A1 Amanda L Dobbyn
A1 Laura Huckins
A1 James Boocock
A1 Claudia Giambartolomei
A1 Panos Roussos
A1 Niamh Mullins
A1 Swapnil Awasthi
A1 Esben Agerbo
A1 Thomas D Als
A1 Carsten Bøcker Pedersen
A1 Jakob Grove
A1 Ralph Kupka
A1 Eline J Regeer
A1 Adebayo Anjorin
A1 Miquel Casas
A1 Cristina Sánchez-Mora
A1 Pamela B Mahon
A1 Shaun M Purcell
A1 Steve McCarroll
A1 Judith Allardyce
A1 Valentina Escott-Price
A1 Liz Forty
A1 Christine Fraser
A1 Marian L Hamshere
A1 George Kirov
A1 Manolis Kogevinas
A1 Josef Frank
A1 Fabian Streit
A1 Jana Strohmaier
A1 Jens Treutlein
A1 Stephanie H Witt
A1 James L Kennedy
A1 John S Strauss
A1 Julie Garnham
A1 Claire O’Donovan
A1 Claire Slaney
A1 Stacy Steinberg
A1 Thorgeir E Thorgeirsson
A1 Martin Hautzinger
A1 Michael Steffens
A1 Ralph Kupka
A1 Steve McCarroll
A1 Roy H Perlis
A1 Miquel Casas
A1 Cristina Sánchez-Mora
A1 Maria Hipolito
A1 William B Lawson
A1 Evaristus A Nwulia
A1 Shawn E Levy
A1 Shaun M Purcell
A1 Tatiana M Foroud
A1 Stéphane Jamain
A1 Allan H Young
A1 James D McKay
A1 Thomas D Als
A1 Carsten Bøcker Pedersen
A1 Jakob Grove
A1 Diego Albani
A1 Peter Zandi
A1 Pamela B Mahon
A1 James B Potash
A1 Peng Zhang
A1 J Raymond DePaulo
A1 Sarah E Bergen
A1 Anders Juréus
A1 Robert Karlsson
A1 Radhika Kandaswamy
A1 Peter McGuffin
A1 Margarita Rivera
A1 Jolanta Lissowska
A1 Roy H Perlis
A1 Cristiana Cruceanu
A1 Susanne Lucae
A1 Pablo Cervantes
A1 Monika Budde
A1 Katrin Gade
A1 Urs Heilbronner
A1 Marianne Giørtz Pedersen
A1 Carsten Bøcker Pedersen
A1 Derek W Morris
A1 Cynthia Shannon Weickert
A1 Thomas W Weickert
A1 Donald J MacIntyre
A1 Jacob Lawrence
A1 Torbjørn Elvsåshagen
A1 Olav B Smeland
A1 Srdjan Djurovic
A1 Simon Xi
A1 Elaine K Green
A1 Piotr M Czerski
A1 Joanna Hauser
A1 Wei Xu
A1 Helmut Vedder
A1 Lilijana Oruc
A1 Anne T Spijker
A1 Scott D Gordon
A1 Sarah E Medland
A1 David Curtis
A1 Thomas W Mühleisen
A1 Judith Badner
A1 William A Scheftner
A1 Engilbert Sigurdsson
A1 Nicholas J Schork
A1 Alan F Schatzberg
A1 Marie Bækvad-Hansen
A1 Jonas Bybjerg-Grauholm
A1 Christine Søholm Hansen
A1 James A Knowles
A1 Helena Medeiros
A1 Szabolcs Szelinger
A1 Grant W Montgomery
A1 Derek W Morris
A1 Marco Boks
A1 Annelie Nordin Adolfsson
A1 Miquel Casas
A1 Stéphane Jamain
A1 Nicholas Bass
A1 David Curtis
A1 Per Hoffmann
A1 Michael Bauer
A1 Andrea Pfennig
A1 Markus Leber
A1 Sarah Kittel-Schneider
A1 Andreas Reif
A1 Katrin Gade
A1 Jurgen Del-Favero
A1 Sascha B Fischer
A1 Stefan Herms
A1 Per Hoffmann
A1 Thomas W Mühleisen
A1 Céline S Reinbold
A1 Srdjan Djurovic
A1 Franziska Degenhardt
A1 Stefan Herms
A1 Per Hoffmann
A1 Anna C Koller
A1 Anna Maaser
A1 Wolfgang Maier
A1 Nelson B Freimer
A1 Anil Ori
A1 Anders M Dale
A1 Chun Chieh Fan
A1 Tiffany A Greenwood
A1 Caroline M Nievergelt
A1 Tatyana Shehktman
A1 Paul D Shilling
A1 Olav B Smeland
A1 William Byerley
A1 William Bunney
A1 Ney Alliey-Rodriguez
A1 Douglas H R Blackwood
A1 Toni-Kim Clarke
A1 Donald J MacIntyre
A1 Margarita Rivera
A1 Chunyu Liu
A1 William Coryell
A1 Huda Akil
A1 Margit Burmeister
A1 Matthew Flickinger
A1 Jun Z Li
A1 Melvin G McInnis
A1 Fan Meng
A1 Robert C Thompson
A1 Stanley J Watson
A1 Sebastian Zollner
A1 Weihua Guan
A1 Melissa J Green
A1 Cynthia Shannon Weickert
A1 Thomas W Weickert
A1 Olav B Smeland
A1 David Craig
A1 Janet L Sobell
A1 Lili Milani
A1 James L Kennedy
A1 John S Strauss
A1 Wei Xu
A1 Katherine Gordon-Smith
A1 Sarah V Knott
A1 Amy Perry
A1 José Guzman Parra
A1 Fermin Mayoral
A1 Fabio Rivas
A1 Miquel Casas
A1 Cristina Sánchez-Mora
A1 Caroline M Nievergelt
A1 Ralph Kupka
A1 John P Rice
A1 Jack D Barchas
A1 Anders D Børglum
A1 Preben Bo Mortensen
A1 Ole Mors
A1 Maria Grigoroiu-Serbanescu
A1 Frank Bellivier
A1 Bruno Etain
A1 Marion Leboyer
A1 Josep Antoni Ramos-Quiroga
A1 Marta Ribasés
A1 Tõnu Esko
A1 Jordan W Smoller
A1 Nicholas Craddock
A1 Ian Jones
A1 Michael J Owen
A1 Marcella Rietschel
A1 Thomas G Schulze
A1 John Vincent
A1 Tõnu Esko
A1 Eduard Vieta
A1 Merete Nordentoft
A1 Martin Alda
A1 Hreinn Stefansson
A1 Kari Stefansson
A1 Danielle Posthuma
A1 Ingrid Agartz
A1 Frank Bellivier
A1 Tõnunu Esko
A1 Ketil J Oedegaard
A1 Eystein Stordal
A1 Josep Antoni Ramos-Quiroga
A1 Marta Ribasés
A1 Richard M Myers
A1 René S Kahn
A1 Frank Bellivier
A1 Bruno Etain
A1 Marion Leboyer
A1 Bruno Etain
A1 Anders D Børglum
A1 Ole Mors
A1 Thomas Werge
A1 Qingqin S Li
A1 Thomas G Schulze
A1 Fernando Goes
A1 Ingrid Agartz
A1 Christina M Hultman
A1 Mikael Landén
A1 Patrick F Sullivan
A1 Cathryn M Lewis
A1 Susan L McElroy
A1 Jordan W Smoller
A1 Bertram Müller-Myhsok
A1 Joanna M Biernacka
A1 Mark Frye
A1 Gustavo Turecki
A1 Guy A Rouleau
A1 Thomas G Schulze
A1 Thomas Werge
A1 Guy A Rouleau
A1 Bertram Müller-Myhsok
A1 Martin Alda
A1 Francis J McMahon
A1 Thomas G Schulze
A1 Janice M Fullerton
A1 Peter R Schofield
A1 Eystein Stordal
A1 Gunnar Morken
A1 Ulrik F Malt
A1 Ingrid Melle
A1 Sara A Paciga
A1 Nicholas G Martin
A1 Arne E Vaaler
A1 Gunnar Morken
A1 David M Hougaard
A1 Carlos Pato
A1 Michele T Pato
A1 Nicholas G Martin
A1 Aiden Corvin
A1 Michael Gill
A1 René S Kahn
A1 Rolf Adolfsson
A1 Josep Antoni Ramos-Quiroga
A1 Frank Bellivier
A1 Bruno Etain
A1 Marion Leboyer
A1 Thomas G Schulze
A1 Bernhard T Baune
A1 Ketil J Oedegaard
A1 Alessandro Serretti
A1 Markus M Nöthen
A1 Elliot S Gershon
A1 Thomas Werge
A1 Andrew M McIntosh
A1 Mikael Landén
A1 Kari Stefansson
A1 Bertram Müller-Myhsok
A1 Michael Boehnke
A1 Udo Dannlowski
A1 Janice M Fullerton
A1 Philip B Mitchell
A1 Peter R Schofield
A1 Patrick F Sullivan
A1 Ingrid Agartz
A1 Ingrid Melle
A1 Wade H Berrettini
A1 Vishwajit Nimgaonkar
A1 Tõnu Esko
A1 Andres Metspalu
A1 Lisa A Jones
A1 Josep Antoni Ramos-Quiroga
A1 Marta Ribasés
A1 John Nurnberger
A1 Naomi R Wray
A1 Arianna Di Florio
A1 Michael C O’Donovan
A1 Howard Edenberg
A1 Roel A Ophoff
A1 Laura J Scott
A1 Sven Cichon
A1 Ole A Andreassen
A1 Pamela Sklar
A1 John Kelsoe
A1 Gerome Breen
A1 for the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium.
YR 2017
UL http://biorxiv.org/content/early/2017/08/08/173062.1.abstract
AB Bipolar disorder is a highly heritable psychiatric disorder that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10−4 in an independent sample of 9,412 cases and 137,760 controls. In the combined analysis, 30 loci achieved genome-wide significance including 20 novel loci. These significant loci contain genes encoding ion channels and neurotransmitter transporters (CACNA1C, GRIN2A, SCN2A, SLC4A1), synaptic components (RIMS1, ANK3), immune and energy metabolism components, and multiple potential therapeutic targets for mood stabilizer drugs. Bipolar disorder type I (depressive and manic episodes; ~73% of our cases) is strongly genetically correlated with schizophrenia whereas type II (depressive and hypomanic episodes; ~17% of our cases) correlated more with major depression. Furthermore, bipolar disorder has a positive genetic correlation with educational attainment yet has no significant genetic correlation with intelligence. These findings address key clinical questions and provide potential new biological mechanisms for bipolar disorder.