RT Journal Article SR Electronic T1 BMP signalling is critical for maintaining homeostasis of hair follicles and intestine in adult mice JF bioRxiv FD Cold Spring Harbor Laboratory SP 174680 DO 10.1101/174680 A1 Aditi Nag A1 Pallavi Nigam A1 Abhishek L. Narayanan A1 Megha Kumar A1 Ritika Ghosal A1 Jonaki Sen A1 Amitabha Bandyopadhyay YR 2017 UL http://biorxiv.org/content/early/2017/08/10/174680.abstract AB BMP signalling play critical roles during embryonic development, however, its roles have not been extensively studied in the maintenance of adult tissue homeostasis. In this study we have used temporal knock out of Bmp2 and Bmp4 to uncover the role of BMP signalling in adult mice. We observed rapid changes in the adult hair follicles and the intestine within two days of depleting BMP signalling, which demonstrates the critical and acute requirement of BMP signalling in maintaining homeostasis in these tissues. In addition, our study demonstrates that while BMP signalling is required for maintenance of quiescence in telogen hair follicles, it is needed for survival and proliferation in late anagen hair follicles. Our study also reveals differential requirement of BMP signalling in differentiation of distinct intestinal cell types. In addition, Loss of BMP signalling rapidly promotes early neoplastic transformations in mouse intestine.