TY - JOUR T1 - GrigoraSNPs: Optimized HTS DNA Forensic SNP Analysis JF - bioRxiv DO - 10.1101/173716 SP - 173716 AU - Darrell O. Ricke AU - Anna Shcherbina AU - Adam Michaleas AU - Philip Fremont-Smith Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/08/11/173716.abstract N2 - High throughput DNA sequencing technologies enable improved characterization of forensic DNA samples enabling greater insights into DNA contributor(s). Current DNA forensics techniques rely upon allele sizing of short tandem repeats by capillary electrophoresis. High throughput sequencing enables forensic sample characterizations for large numbers of single nucleotide polymorphism loci. The slowest computational component of the DNA forensics analysis pipeline is the characterization of raw sequence data. This paper optimizes the SNP calling module of the DNA analysis pipeline with runtime results that scale linearly with the number of HTS sequences (patent pending)[1]. GrigoraSNPs can analyze 100 million reads in less than 5 minutes using 3 threads on a 4.0 GHz Intel i7-6700K laptop CPU. Compared to standard bioinformatics pipelines that run for hours on servers, GrigoraSNPs enables rapid sample analysis. ER -