RT Journal Article
SR Electronic
T1 On the relative role of different age groups during epidemics associated with the respiratory syncytial virus
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 173351
DO 10.1101/173351
A1 E. Goldstein
A1 H. H. Nguyen
A1 P. Liu
A1 C. Viboud
A1 C.A. Steiner
A1 C. J. Worby
A1 M. Lipsitch
YR 2017
UL http://biorxiv.org/content/early/2017/08/11/173351.abstract
AB Background While RSV circulation results in high burden of hospitalization, particularly among infants, young children and the elderly, little is known about the role of different age groups in propagating annual RSV epidemics in the community.Methods During a communicable disease outbreak, some subpopulations may play a disproportionate role during the outbreak's ascent due to increased susceptibility and/or contact rates. Such subpopulations can be identified by considering the proportion that cases in a subpopulation represent among all cases in the population occurring before (Bp) and after the epidemic peak (Ap) to calculate the subpopulation's relative risk, RR=Bp/Ap. We estimated RR for several age groups using data on RSV hospitalizations in the US between 2001-2012 from the Healthcare Cost and Utilization Project (HCUP).Results Children aged 3-4y and 5-6y each had the highest RR estimate for 5/11 seasons in the data, with RSV hospitalization rates in infants being generally higher during seasons when children aged 5-6y had the highest RR estimates. Children aged 2y had the highest RR estimate during one season. RR estimates in infants and individuals aged 11y and older were mostly lower than in children aged 1-10y.Conclusions The RR estimates suggest that preschool and young school-age children have the leading relative roles during RSV epidemics. We hope that those results will aid in the design of RSV vaccination policies.