RT Journal Article
SR Electronic
T1 Common variants of <em>NRXN1, LRP1B</em> and <em>RORA</em> are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 175489
DO 10.1101/175489
A1 Ney Alliey-Rodriguez
A1 Tamar A Grey
A1 Rebecca Shafee
A1 Jaya Padmanabhan
A1 Neeraj Tandon
A1 Madeline Klinger
A1 Jonathan Spring
A1 Lucas Coppes
A1 Katherine Reis
A1 Matcheri S Keshavan
A1 Diane Gage
A1 Steven McCarroll
A1 Jeffrey R Bishop
A1 Scot Hill
A1 James L Reilly
A1 Rebekka Lencer
A1 Brett Clementz
A1 Peter Buckley
A1 Shashwath Meda
A1 Balaji Narayanan
A1 David C Glahn
A1 Godfrey Pearlson
A1 Elena I Ivleva
A1 Carol Tamminga
A1 John A Sweeney
A1 David Curtis
A1 Sarah Keedy
A1 Judith A Badner
A1 Chunyu Liu
A1 Elliot S Gershon
YR 2017
UL http://biorxiv.org/content/early/2017/08/11/175489.abstract
AB Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1, and the volume of the cavum septum pellucidum was associated with LRP1B and RORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. This is the first report of common genetic variants associated with these intermediate phenotypes.