PT  - JOURNAL ARTICLE
AU  - Heeju Noh
AU  - Jason E. Shoemaker
AU  - Rudiyanto Gunawan
TI  - SALMON: inferring protein targets of compounds by network-based analysis of gene transcriptional profiles
AID  - 10.1101/175364
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 175364
4099  - http://biorxiv.org/content/early/2017/08/11/175364.short
4100  - http://biorxiv.org/content/early/2017/08/11/175364.full
AB  - We present SALMON, a method for identifying protein targets of compounds using cell-type specific protein-gene networks and gene transcriptional profiles. For benchmark datasets from three drug treatment studies, SALMON was able to provide highly accurate target predictions, with an average area under receiver operating characteristic of 0.82. SALMON was also able to reveal the mechanism of action of DNA-damaging compounds in NCI-DREAM drug synergy study with high sensitivity and specificity.