RT Journal Article
SR Electronic
T1 Pathway-Level Integration of Proteogenomic Data in Breast Cancer Using Independent Component Analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 175687
DO 10.1101/175687
A1 Wenke Liu
A1 Sisi Ma
A1 David Fenyö
YR 2017
UL http://biorxiv.org/content/early/2017/08/13/175687.abstract
AB Recent advances in the multi-omics characterization necessitate pathway-level abstraction and knowledge integration across different data types. In this study, we apply independent component analysis (ICA) to human breast cancer proteogenomics data to retrieve mechanistic information. We show that as an unsupervised feature extraction method, ICA was able to construct signatures with known biological relevance on both transcriptome and proteome levels. Moreover, proteome and transcriptome signatures can be associated by their respective correlation with patient clinical features, providing an integrated description of phenotype-related biological processes. Our results demonstrate that the application of ICA to proteogenomics data could lead to pathway-level knowledge discovery. Potential extension of this approach to other data and cancer types may contribute to pan-cancer integration of multi-omics information.