PT  - JOURNAL ARTICLE
AU  - Anna Varizhuk
AU  - Dmitry Ischenko
AU  - Igor Smirnov
AU  - Olga Tatarinova
AU  - Vyacheslav Severov
AU  - Roman Novikov
AU  - Vladimir Tsvetkov
AU  - Vladimir Naumov
AU  - Dmitry Kaluzhny
AU  - Galina Pozmogova
TI  - An Improved Search Algorithm to Find G-Quadruplexes in Genome Sequences
AID  - 10.1101/001990
DP  - 2014 Jan 01
TA  - bioRxiv
PG  - 001990
4099  - http://biorxiv.org/content/early/2014/01/23/001990.short
4100  - http://biorxiv.org/content/early/2014/01/23/001990.full
AB  - A growing body of data suggests that the secondary structures adopted by G-rich polynucleotides may be more diverse than previously thought and that the definition of G-quadruplex-forming sequences should be broadened. We studied solution structures of a series of naturally occurring and model single-stranded DNA fragments defying the G3+NL1G3+NL2G3+NL3G3+ formula, which is used in most of the current GQ-search algorithms. The results confirm the GQ-forming potential of such sequences and suggest the existence of new types of GQs. We developed an improved (broadened) GQ-search algorithm (http://niifhm.ru/nauchnye-issledovanija/otdel-molekuljarnoj-biologii-i-genetiki/laboratorija-iskusstvennogo-antitelogeneza/497-2/) that accounts for the recently reported new types of GQs.