RT Journal Article
SR Electronic
T1 Predicting competition results from growth curves
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 022640
DO 10.1101/022640
A1 Yoav Ram
A1 Eynat Dellus-Gur
A1 Uri Obolski
A1 Maayan Bibi
A1 Judith Berman
A1 Lilach Hadany
YR 2015
UL http://biorxiv.org/content/early/2015/07/23/022640.abstract
AB Measuring relative fitness by pairwise competition experiments is laborious and expensive. Accordingly, many investigators estimate fitness from the maximum growth rate during exponential growth. However, maximum growth rates have been shown to be an unreliable measure of fitness as indicated by discrepancies between these parameters and the outcomes of pairwise competition experiments. Here we propose a new method that estimates relative fitness by predicting the results of competition experiments from single strain growth curves.