PT  - JOURNAL ARTICLE
AU  - Hong-Dong Li
AU  - Qing-Song Xu
AU  - Yi-Zeng Liang
TI  - A phase diagram for gene selection and disease classification
AID  - 10.1101/002360
DP  - 2014 Jan 01
TA  - bioRxiv
PG  - 002360
4099  - http://biorxiv.org/content/early/2014/02/04/002360.short
4100  - http://biorxiv.org/content/early/2014/02/04/002360.full
AB  - Identifying a small subset of discriminate genes is important for predicting clinical outcomes and facilitating disease diagnosis. Based on the model population analysis framework, we present a method, called PHADIA, which is able to output a phase diagram displaying the predictive ability of each variable, which provides an intuitive way for selecting informative variables. Using two publicly available microarray datasets, it’s demonstrated that our method can selects a few informative genes and achieves significantly better or comparable classification accuracy compared to the reported results in the literature. The source codes are freely available at: www.libpls.net.