PT - JOURNAL ARTICLE AU - István Bartha AU - Paul J McLaren AU - Chanson Brumme AU - Richard Harrigan AU - Amalio Telenti AU - Jacques Fellay TI - Estimating the respective contributions of human and viral genetic variation to HIV control AID - 10.1101/029017 DP - 2015 Jan 01 TA - bioRxiv PG - 029017 4099 - http://biorxiv.org/content/early/2015/10/14/029017.short 4100 - http://biorxiv.org/content/early/2015/10/14/029017.full AB - We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.