TY - JOUR T1 - The Great Migration and African-American genomic diversity JF - bioRxiv DO - 10.1101/029173 SP - 029173 AU - Soheil Baharian AU - Maxime Barakatt AU - Christopher R. Gignoux AU - Suyash Shringarpure AU - Jacob Errington AU - William J. Blot AU - Carlos D. Bustamante AU - Eimear E. Kenny AU - Scott M. Williams AU - Melinda C. Aldrich AU - Simon Gravel Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/10/15/029173.abstract N2 - Genetic studies of African-Americans identify functional variants, elucidate historical and genealogical mysteries, and reveal basic biology. However, African-Americans have been under-represented in genetic studies, and little is known about nation-wide patterns of genomic diversity in the population. Here, we present a comprehensive assessment of African-American genomic diversity using genotype data from nationally and regionally representative cohorts. We find higher African ancestry in southern United States compared to the North and West. We show that relatedness patterns track north- and west-bound routes followed during the Great Migration, suggesting that admixture occurred predominantly in the South prior to the Civil War and that ancestry-biased migration is responsible for regional differences in ancestry. Rare genetic traits among African-Americans can therefore be shared over long geographic distances along the Great Migration routes, yet their distribution over short distances remains highly structured. This study clarifies the role of recent demography in shaping African-American genomic diversity. ER -