TY - JOUR T1 - Reconstructing Genetic History of Siberian and Northeastern European Populations JF - bioRxiv DO - 10.1101/029421 SP - 029421 AU - Emily HM Wong AU - Andrey Khrunin AU - Larissa Nichols AU - Dmitry Pushkarev AU - Denis Khokhrin AU - Dmitry Verbenko AU - Oleg Evgrafov AU - James Knowles AU - John Novembre AU - Svetlana Limborska AU - Anton Valouev Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/10/20/029421.abstract N2 - Siberia and Western Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups. Yet, genetic variation of peoples from this region is largely uncharacterized. We present whole-genome sequencing data from 28 individuals belonging to 14 distinct indigenous populations from that region. We combine these datasets with additional 32 modern-day and 15 ancient human genomes to build and compare autosomal, Y-DNA and mtDNA trees. Our results provide new links between modern and ancient inhabitants of Eurasia. Siberians share 38% of ancestry with descendants of the 45,000-year-old Ust’-Ishim people, who were previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to the Ancient North Eurasians, represented by the 24,000-year-old Siberian Mal’ta boy. In addition, Siberians admixtures are present in lineages represented by Eastern European hunter-gatherers from Samara, Karelia, Hungary and Sweden (from 8,000-6,600 years ago), as well as Yamnaya culture people (5,300-4,700 years ago) and modern-day northeastern Europeans. These results provide new evidence of ancient gene flow from Siberia into Europe. ER -