RT Journal Article
SR Electronic
T1 Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 031245
DO 10.1101/031245
A1 Chun Chen
A1 John J. Tyson
A1 William T. Baumann
YR 2015
UL http://biorxiv.org/content/early/2015/11/10/031245.abstract
AB We present a mathematical model that captures the transitions among three experimentally observed estrogen-sensitivity phenotypes in breast cancer cells. Based on this model, a population-level model is created and used to explore the optimization of a therapeutic protocol