@article {Okbay032789, author = {Aysu Okbay and Bart M.L. Baselmans and Jan-Emmanuel De Neve and Patrick Turley and Michel G. Nivard and Mark A. Fontana and S. Fleur W. Meddens and Richard Karlsson Linn{\'e}r and Cornelius A. Rietveld and Jaime Derringer and Jacob Gratten and James J. Lee and Jimmy Z. Liu and Ronald de Vlaming and Tarunveer S. Ahluwalia and Jadwiga Buchwald and Alana Cavadino and Alexis C. Frazier-Wood and Nicholas A. Furlotte and Victoria Garfield and Marie Henrike Geisel and Juan R. Gonzalez and Saskia Haitjema and Robert Karlsson and Sander W. van der Laan and Karl-Heinz Ladwig and Jari Lahti and Sven J. van der Lee and Penelope A. Lind and Tian Liu and Lindsay Matteson and Evelin Mihailov and Michael B. Miller and Camelia C. Minica and Ilja M. Nolte and Dennis Mook-Kanamori and Peter J. van der Most and Christopher Oldmeadow and Yong Qian and Olli Raitakari and Rajesh Rawal and Anu Realo and Rico Rueedi and B{\"o}rge Schmidt and Albert V. Smith and Evie Stergiakouli and Toshiko Tanaka and Kent Taylor and Juho Wedenoja and Juergen Wellmann and Harm-Jan Westra and Sara M. Willems and Wei Zhao and Behrooz Z. Alizadeh and Najaf Amin and Andrew Bakshi and Patricia A. Boyle and Simon Cox and Gail Davies and Oliver S.P. Davis and Jun Ding and Nese Direk and Peter Eibich and Rebecca T. Emeny and Ghazaleh Fatemifar and Jessica D. Faul and Luigi Ferrucci and Andreas J. Forstner and Christian Gieger and Tamara B. Harris and Juliette M. Harris and Elizabeth G. Holliday and Jouke-Jan Hottenga and Philip L. De Jager and Marika A. Kaakinen and Eero Kajantie and Ville Karhunen and Ivana Kolcic and Meena Kumari and Lenore J. Launer and LifeLines Cohort Study and Ruifang Li-Gao and Marisa Loitfelder and Anu Loukola and Pedro Marques-Vidal and Grant W. Montgomery and Lavinia Paternoster and Alison Pattie and Katja E. Petrovic and Laura Pulkki-R{\r a}back and Lydia Quaye and Katri R{\"a}ikk{\"o}nen and Igor Rudan and Rodney J. Scott and Jennifer A. Smith and Angelina R. Sutin and Maciej Trzaskowski and Anna E. Vinkhuyzen and Lei Yu and Delilah Zabaneh and John R. Attia and David A. Bennett and Klaus Berger and Lars Bertram and Dorret I. Boomsma and Ute Bultmann and Shun-Chiao Chang and Francesco Cucca and Ian J. Deary and Cornelia M. van Duijn and Johan G. Eriksson and Lude Franke and Eco J.C. de Geus and Patrick J.F. Groenen and Vilmundur Gudnason and Torben Hansen and Catharine A. Hartman and Claire M.A. Haworth and Caroline Hayward and Andrew C. Heath and David A. Hinds and Elina Hypp{\"o}nen and William G. Iacono and Marjo-Riitta J{\"a}rvelin and Karl-Heinz J{\"o}ckel and Jaakko Kaprio and Sharon L.R. Kardia and Liisa Keltikangas-J{\"a}rvinen and Peter Kraft and Laura Kubzansky and Terho Lehtim{\"a}ki and Patrik K.E. Magnusson and Nicholas G. Martin and Matt McGue and Andres Metspalu and Melinda Mills and Ren{\'e}e de Mutsert and Albertine J. Oldehinkel and Gerard Pasterkamp and Nancy L. Pedersen and Robert Plomin and Ozren Polasek and Christine Power and Stephen S. Rich and Frits R. Rosendaal and Hester M. den Ruijter and David Schlessinger and Helena Schmidt and Rauli Svento and Reinhold Schmidt and Harold Snieder and Thorkild I.A. S{\o}rensen and Tim D. Spector and Andrew Steptoe and Antonio Terracciano and A. Roy Thurik and Nicholas J. Timpson and Henning Tiemeier and Andr{\'e} G. Uitterlinden and Peter Vollenweider and Gert Wagner and David R. Weir and Jian Yang and Dalton C. Conley and George Davey Smith and Albert Hofman and Magnus Johannesson and David I. Laibson and Sarah E. Medland and Michelle N. Meyer and Joseph K. Pickrell and T{\~o}nu Esko and Robert F. Krueger and Jonathan P. Beauchamp and Philipp D. Koellinger and Daniel J. Benjamin and Meike Bartels and David Cesarini}, title = {Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism}, elocation-id = {032789}, year = {2015}, doi = {10.1101/032789}, publisher = {Cold Spring Harbor Laboratory}, abstract = {We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms ({\textquotedblleft}DS{\textquotedblright}; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB . We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.One Sentence Summary: Using both genome-wide association studies and proxy-phenotype studies, we identify genetic variants associated with subjective well-being, depressive symptoms, and neuroticism.}, URL = {https://www.biorxiv.org/content/early/2015/11/24/032789}, eprint = {https://www.biorxiv.org/content/early/2015/11/24/032789.full.pdf}, journal = {bioRxiv} }