RT Journal Article
SR Electronic
T1 Multiscale Modeling of Cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 033977
DO 10.1101/033977
A1 Kerri-Ann Norton
A1 Meghan McCabe Pryor
A1 Aleksander S. Popel
YR 2015
UL http://biorxiv.org/content/early/2015/12/08/033977.abstract
AB Breast cancer remains the second leading cause of cancer death in women, exceeded only by lung cancer. Specifically, triple-negative breast cancer (TNBC) has the worst prognosis, as it is more invasive and lacks estrogen, progesterone, and HER2 receptors that can be targeted with therapies. Due to the need for effective therapies for this type of breast cancer, it is critical to develop methods to (1) understand how TNBC progresses and (2) facilitate development of effective therapies. Here, we describe a multiscale model focusing on tumor formation. Our approach uses multiple scales to investigate the progression and possible treatments of tumors.