TY - JOUR T1 - The <em>Drosophila</em> Neurogenin, Tap, controls axonal growth through the Wnt adaptor protein Dishevelled JF - bioRxiv DO - 10.1101/034439 SP - 034439 AU - Liqun Yuan AU - Shu Hu AU - Zeynep Okray AU - Xi Ren AU - Natalie De Geest AU - Annelies Claeys AU - Jiekun Yan AU - Eric Bellefroid AU - Bassem A. Hassan AU - Xiao-Jiang Quan Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/12/15/034439.abstract N2 - The Neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, their function in neurite growth is poorly understood. Drosophila has a single predicted Ngn homologue called Tap, whose function is completely unknown. Here we show that Tap is not a proneural protein in Drosophila but is required for proper axonal growth and guidance of neurons of the mushroom body (MB), a neuropile required for associative learning and memory. Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein, Dishevelled.Summary The Drosophila Neurogenin homologue, Target of Pox neuro (Tap), prevents axonal overgrowth by regulating the Wnt Planar Cell Polarity pathway adaptor protein Dishevelled. ER -