TY - JOUR T1 - Comparative evaluation of the genomes of common bacterial members of the <em>Drosophila</em> intestinal community JF - bioRxiv DO - 10.1101/036020 SP - 036020 AU - Kristina Petkau AU - David Fast AU - Aashna Duggal AU - Edan Foley Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/01/05/036020.abstract N2 - Drosophila melanogaster is an excellent model to explore the molecular exchanges that occur between an animal intestine and their microbial passengers. For example, groundbreaking studies in flies uncovered a sophisticated web of host responses to intestinal bacteria. The outcomes of these responses define critical events in the host, such as the establishment of immune responses, access to nutrients, and the rate of larval development. Despite our steady march towards illuminating the host machinery that responds to bacterial presence in the gut, we know remarkably little about the microbial products that influence bacterial association with a fly host. To address this deficiency, we sequenced and characterized the genomes of three common Drosophila-associated microbes: Lactobacillus plantarum, Lactobacillus brevis and Acetobacter pasteurianus. In each case, we compared the genomes of Drosophila-associated strains to the genomes of strains isolated from alternative sources. This approach allowed us to identify molecular functions common to Drosophila-associated microbes, and, in the case of A. pasteurianus, to identify genes that are essential for association with the host. Of note, many of the gene products unique to fly-associated strains have established roles in the stabilization of host-microbe interactions. We believe that these data provide a valuable starting point for a more thorough examination of the microbial perspective on host-microbe relationships. ER -