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The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Ghaddar N, Wang S, Woodvine B, Krishnamoorthy J, van Hoef V, Darini C, Kazimierczak U, Ah-Son N, Popper H, Johnson M, Officer L, Teodósio A, Broggini M, Mann KK, Hatzoglou M, Topisirovic I, Larsson O, Le Quesne J, Koromilas AE. Ghaddar N, et al. Among authors: darini c. Nat Commun. 2021 Jul 30;12(1):4651. doi: 10.1038/s41467-021-24661-0. Nat Commun. 2021. PMID: 34330898 Free PMC article.
Lopinavir co-induces insulin resistance and ER stress in human adipocytes.
Djedaini M, Peraldi P, Drici MD, Darini C, Saint-Marc P, Dani C, Ladoux A. Djedaini M, et al. Among authors: darini c. Biochem Biophys Res Commun. 2009 Aug 14;386(1):96-100. doi: 10.1016/j.bbrc.2009.05.148. Epub 2009 Jun 6. Biochem Biophys Res Commun. 2009. PMID: 19501568
Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
Krishnamoorthy J, Tenkerian C, Gupta J, Ghaddar N, Wang S, Darini C, Staschke KA, Ghosh A, Gandin V, Topisirovic I, Kristof AS, Hatzoglou M, Simos G, Koromilas AE. Krishnamoorthy J, et al. Among authors: darini c. Cell Death Dis. 2018 Feb 15;9(3):254. doi: 10.1038/s41419-018-0326-2. Cell Death Dis. 2018. PMID: 29449538 Free PMC article.