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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.
Cell. 2023 Jan 19;186(2):346-362.e17. doi: 10.1016/j.cell.2022.12.025. Epub 2023 Jan 12.
Cell. 2023.
PMID: 36638793
Free PMC article.
Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.
Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J.
Wang HY, et al. Among authors: oltion k.
Nat Chem. 2022 Dec;14(12):1443-1450. doi: 10.1038/s41557-022-01039-3. Epub 2022 Sep 19.
Nat Chem. 2022.
PMID: 36123449
Free PMC article.
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The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center.
Coelho JPL, Yip MCJ, Oltion K, Taunton J, Shao S.
Coelho JPL, et al. Among authors: oltion k.
Nat Chem Biol. 2024 Jan 3. doi: 10.1038/s41589-023-01521-0. Online ahead of print.
Nat Chem Biol. 2024.
PMID: 38172604
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Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions.
Shao H, Oltion K, Wu T, Gestwicki JE.
Shao H, et al. Among authors: oltion k.
Org Biomol Chem. 2020 Jun 10;18(22):4157-4163. doi: 10.1039/d0ob00928h.
Org Biomol Chem. 2020.
PMID: 32458889
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Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.
Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS.
Mavor D, et al. Among authors: oltion k.
Biol Open. 2018 Jul 23;7(7):bio036103. doi: 10.1242/bio.036103.
Biol Open. 2018.
PMID: 30037883
Free PMC article.
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