User profiles for A. C. McHardy

Alice Carolyn McHardy

Helmholtz Centre for Infection Research, Germany
Verified email at helmholtz-hzi.de
Cited by 27021

The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins

…, K Huthmacher, R Krämer, B Linke, AC McHardy… - Journal of …, 2003 - Elsevier
… Phenotypic analysis and enzyme activity measurements of a C. glutamicum mutant with a
deletion of dapF resulted in the unequivocal identification of this gene (Hartmann et al., 2003). …

[HTML][HTML] Eleven grand challenges in single-cell data science

…, FJ Theis, H Yang, A Zelikovsky, AC McHardy… - Genome biology, 2020 - Springer
The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

…, S Lebeer, AJ Macpherson, RC Massey, AC McHardy… - Nature, 2023 - nature.com
Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and
placenta) are stably colonized by microbial communities in a healthy pregnancy remains a …

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes

…, M Kubal, N Larsen, B Linke, AC McHardy… - Nucleic acids …, 2005 - academic.oup.com
… Two forms of yngF (encoding the methylcrotonyl-CoA carboxylase biotin-containing subunit
(EC 6.4.1.4) were observed—the most common form, a fusion of biotin carboxylase and a C-…

Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite

…, TH Richardson, JT Stege, M Cayouette, AC McHardy… - Nature, 2007 - nature.com
From the standpoints of both basic research and biotechnology, there is considerable interest
in reaching a clearer understanding of the diversity of biological mechanisms employed …

[PDF][PDF] Structure and function of the bacterial root microbiota in wild and domesticated barley

…, PC Münch, A Weiman, J Dröge, Y Pan, AC McHardy… - Cell host & …, 2015 - cell.com
The microbial communities inhabiting the root interior of healthy plants, as well as the
rhizosphere, which consists of soil particles firmly attached to roots, engage in symbiotic …

Functional overlap of the Arabidopsis leaf and root microbiota

…, M Remus-Emsermann, B Hüttel, AC McHardy… - Nature, 2015 - nature.com
Roots and leaves of healthy plants host taxonomically structured bacterial assemblies, and
members of these communities contribute to plant growth and health. We established …

Defining seasonal marine microbial community dynamics

…, J Reeder, B Temperton, S Huse, AC McHardy… - The ISME …, 2012 - academic.oup.com
Here we describe, the longest microbial time-series analyzed to date using high-resolution
16S rRNA tag pyrosequencing of samples taken monthly over 6 years at a temperate marine …

GenDB—an open source genome annotation system for prokaryote genomes

F Meyer, A Goesmann, AC McHardy… - Nucleic acids …, 2003 - academic.oup.com
… of certain features of coding sequences, such as TMHMM (16) for the prediction of α‐helical
transmembrane regions, SignalP (17) for signal peptide prediction, or CoBias (ACMcHardy

[HTML][HTML] Critical assessment of metagenome interpretation—a benchmark of metagenomics software

…, EM Rubin, AE Darling, T Rattei, AC McHardy - Nature …, 2017 - nature.com
… (ac) Fractions of reference genomes assembled by each assembler for all genomes (a),
genomes with ANI < 95% (b) and genomes with ANI ≥95% (c). Colors indicate results from the …