The last few years have seen the development of large efforts for the analysis of genome
function, especially in the context of genome variation. One of the most prominent directions …

To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …

Genetic variation influences gene expression, and this variation in gene expression can be
efficiently mapped to specific genomic regions and variants. Here we have used gene …

… The correlation observed between monozygotic twins thus provides an estimate of A + C. In
… dizygotic twins is a direct estimate of 0.5 A + C. Consequently, twice the difference between …

The identification of complex disease susceptibility loci through genome-wide association
studies (GWAS) has recently become possible and is now a method of choice for investigating …

We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …

The genetic basis of gene expression variation has long been studied with the aim to
understand the landscape of regulatory variants, but also more recently to assist in the …

The recent success of genome-wide association studies (GWAS) is now followed by the
challenge to determine how the reported susceptibility variants mediate complex traits and …

While there have been studies exploring regulatory variation in one or more tissues, the
complexity of tissue-specificity in multiple primary tissues is not yet well understood. We explore …

… We also showed evidence of the importance of using disease-targeted tissue or cell panels
for accurate interpretation of functionality of disease loci from genome-wide association …