SMN-A chaperone for nuclear RNP social occasions?
Survival Motor Neuron (SMN) protein localizes to both the nucleus and the cytoplasm.
Cytoplasmic SMN is diffusely localized in large oligomeric complexes with core member proteins, …
Cytoplasmic SMN is diffusely localized in large oligomeric complexes with core member proteins, …
[HTML][HTML] Comprehensive Modeling of Spinal Muscular Atrophy in Drosophila melanogaster
AM Spring, AC Raimer, CD Hamilton… - Frontiers in molecular …, 2019 - frontiersin.org
… n-values are the same for panels (A–C). Statistical analysis: values above the data indicate
… (A–C) Survival curves for adult flies expressing Smn missense mutations. Data is split into …
… (A–C) Survival curves for adult flies expressing Smn missense mutations. Data is split into …
Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron
…, TR Bonacci, AD Ebert, AC Raimer… - Molecular biology of …, 2018 - Am Soc Cell Biol
Spinal muscular atrophy (SMA) is caused by homozygous mutations in human SMN1.
Expression of a duplicate gene (SMN2) primarily results in skipping of exon 7 and production of …
Expression of a duplicate gene (SMN2) primarily results in skipping of exon 7 and production of …
Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer
K Gupta, Y Wen, NS Ninan, AC Raimer… - Nucleic Acids …, 2021 - academic.oup.com
… have three conserved domains: an N-terminal region responsible for binding to Gemin2,
a centrally located Tudor domain important for binding to Sm-class splicing factors, and a C-…
a centrally located Tudor domain important for binding to Sm-class splicing factors, and a C-…
Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster
AG Matera, AC Raimer, CA Schmidt… - G3: Genes …, 2019 - academic.oup.com
Spinal Muscular Atrophy (SMA) is caused by homozygous mutations in the human survival
motor neuron 1 (SMN1) gene. SMN protein has a well-characterized role in the biogenesis of …
motor neuron 1 (SMN1) gene. SMN protein has a well-characterized role in the biogenesis of …
[PDF][PDF] Assessing changes in student engagement using a mixed-methods approach
JK LAU, J MEKOLICHICK, AC RAIMER… - … of Transformation in …, 2023 - vtechworks.lib.vt.edu
Our Howard Hughes Medical Institute (HHMI) Inclusive Excellence program, REALising
Inclusive Science Excellence (REALISE), focuses strategically and simultaneously on faculty …
Inclusive Science Excellence (REALISE), focuses strategically and simultaneously on faculty …
Temperature-sensitive spinal muscular atrophy-causing point mutations lead to SMN instability, locomotor defects and premature lethality in Drosophila
AC Raimer, SS Singh, MR Edula… - Disease Models & …, 2020 - journals.biologists.com
Spinal muscular atrophy (SMA) is the leading genetic cause of death in young children, arising
from homozygous deletion or mutation of the survival motor neuron 1 (SMN1) gene. SMN …
from homozygous deletion or mutation of the survival motor neuron 1 (SMN1) gene. SMN …
Dysregulation of innate immune signaling in animal models of Spinal Muscular Atrophy
EL Garcia, RE Steiner, AC Raimer, LE Herring… - bioRxiv, 2023 - biorxiv.org
Background: Spinal Muscular Atrophy (SMA) is a devastating neuromuscular disease caused
by hypomorphic loss of function in the Survival Motor Neuron (SMN) protein. SMA presents …
by hypomorphic loss of function in the Survival Motor Neuron (SMN) protein. SMA presents …
[PDF][PDF] Assessing Changes in Student Engagement Using a Mixed-Methods Approach
AC Raimer, JK Lau, J Mekolichick… - … of Transformation in …, 2024 - vtechworks.lib.vt.edu
Our Howard Hughes Medical Institute (HHMI) Inclusive Excellence program, REALising
Inclusive Science Excellence (REALISE), focuses strategically and simultaneously on faculty …
Inclusive Science Excellence (REALISE), focuses strategically and simultaneously on faculty …
Temperature sensitive SMA-causing point mutations lead to SMN instability, locomotor defects, and premature lethality in Drosophila
AC Raimer, SS Singh, MR Edula, T Paris-Davila… - bioRxiv, 2019 - biorxiv.org
Spinal muscular atrophy (SMA) is the leading genetic cause of death in young children, arising
from homozygous deletion or mutation of the SMN1 gene. SMN protein expressed from a …
from homozygous deletion or mutation of the SMN1 gene. SMN protein expressed from a …