[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
[PDF][PDF] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
…, MJ Navarro, JE Bowen, MA Tortorici, AC Walls… - cell, 2020 - cell.com
… To measure expression, we fluorescently labeled the RBD protein on the yeast surface
via a C-terminal epitope tag and used FACS to collect $15 million cells from each library, …
via a C-terminal epitope tag and used FACS to collect $15 million cells from each library, …
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
…, JT Brown, WK Sharkey, KR Sprouse, AC Walls… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the …
concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the …
[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
…, DL Mallery, OJ Charles, JE Bowen, A Joshi, AC Walls… - Nature, 2022 - nature.com
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
[HTML][HTML] Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …
infection is crucial for understanding immune protection and identifying targets for …
[HTML][HTML] Sensitivity of SARS-CoV-2 B. 1.1. 7 to mRNA vaccine-elicited antibodies
… Human ACE2–Fc (residues 1–615 with a C-terminal thrombin cleavage site and human Fc
tag) was synthesized by Twist. Clarified supernatants were affinity-purified using a Protein A …
tag) was synthesized by Twist. Clarified supernatants were affinity-purified using a Protein A …
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern evades antibody-mediated immunity that comes from vaccination or infection with …
concern evades antibody-mediated immunity that comes from vaccination or infection with …
SARS-CoV-2 immune evasion by the B. 1.427/B. 1.429 variant of concern
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …
[HTML][HTML] SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
…, AS Dingens, JE Bowen, MA Tortorici, AC Walls… - Nature, 2021 - nature.com
… (+) or pTwist-CMV) encoding the spike proteins from various sarbecoviruses with a C-terminal
deletion of 19 amino acids (D19) were synthesized for SARS-CoV-2 (GenBank: …
deletion of 19 amino acids (D19) were synthesized for SARS-CoV-2 (GenBank: …