Both oncogenic mutations and cancer tissue-of-origin influence BCAA metabolism and
expression of BCAA-associated metabolic enzymes. These new discoveries need to be taken …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Rfam is a collection of RNA sequence families, represented by multiple sequence alignments
and covariance models (CMs). The primary aim of Rfam is to annotate new members of …

Cell and gene therapies using haematopoietic stem cells (HSCs) epitomize the transformative
potential of regenerative medicine. Recent clinical successes for gene therapies involving …

The illusion of knowing is the belief that comprehension has been attained when, in fact,
comprehension has failed. In the present experiment, the illusion was defined operationally as …

Reconstruction of the molecular pathways controlling organ development has been hampered
by a lack of methods to resolve embryonic progenitor cells. Here we describe a strategy to …

Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood
system after transplantation 1 , which is a curative therapy for numerous diseases including …

Mouse embryonic stem cells derived from the epiblast 1 contribute to the somatic lineages
and the germline but are excluded from the extra-embryonic tissues that are derived from the …

Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

A specialized bone marrow microenvironment (niche) regulates hematopoietic stem cell (HSC)
self-renewal and commitment. For successful donor-HSC engraftment, the niche must be …