User profiles for A. D. Kostic

Aleksandar David Kostic

Assistant Professor, Harvard Medical School & Joslin Diabetes Center
Verified email at joslin.harvard.edu
Cited by 22523

The microbiome in inflammatory bowel disease: current status and the future ahead

AD Kostic, RJ Xavier, D Gevers - Gastroenterology, 2014 - Elsevier
Studies of the roles of microbial communities in the development of inflammatory bowel
disease (IBD) have reached an important milestone. A decade of genome-wide association …

Exploring host–microbiota interactions in animal models and humans

AD Kostic, MR Howitt, WS Garrett - Genes & development, 2013 - genesdev.cshlp.org
The animal and bacterial kingdoms have coevolved and coadapted in response to environmental
selective pressures over hundreds of millions of years. The meta'omics revolution in …

[PDF][PDF] Inflammatory bowel disease as a model for translating the microbiome

C Huttenhower, AD Kostic, RJ Xavier - Immunity, 2014 - cell.com
The inflammatory bowel diseases (IBDs) are among the most closely studied chronic inflammatory
disorders that involve environmental, host genetic, and commensal microbial factors. …

The mutational landscape of head and neck squamous cell carcinoma

N Stransky, AM Egloff, AD Tward, AD Kostic… - science, 2011 - science.org
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing …

[PDF][PDF] The treatment-naive microbiome in new-onset Crohn's disease

…, SJ Song, M Yassour, XC Morgan, AD Kostic… - Cell host & …, 2014 - cell.com
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked
to host pathways that implicate an underlying role for aberrant immune responses to …

[HTML][HTML] Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment

AD Kostic, E Chun, L Robertson, JN Glickman… - Cell host & …, 2013 - cell.com
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses
indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, …

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

AD Kostic, D Gevers, CS Pedamallu… - Genome …, 2012 - genome.cshlp.org
The tumor microenvironment of colorectal carcinoma is a complex community of genomically
altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each …

[PDF][PDF] Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans

T Vatanen, AD Kostic, E d'Hennezel, H Siljander… - Cell, 2016 - cell.com
According to the hygiene hypothesis, the increasing incidence of autoimmune diseases in
western countries may be explained by changes in early microbial exposure, leading to …

[PDF][PDF] The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

AD Kostic, D Gevers, H Siljander, T Vatanen… - Cell host & …, 2015 - cell.com
Kostic et al. perform a microbiome analysis of type 1 diabetes (T1D), examining the infant
gut microbiome as T1D develops. Microbial metabolic pathways remain remarkably stable …

Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis

…, J Yang, R Dou, Y Masugi, M Song, AD Kostic… - Gut, 2016 - gut.bmj.com
Objective Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis.
Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-…