User profiles for A. D. Kostic
Aleksandar David KosticAssistant Professor, Harvard Medical School & Joslin Diabetes Center Verified email at joslin.harvard.edu Cited by 22523 |
The microbiome in inflammatory bowel disease: current status and the future ahead
Studies of the roles of microbial communities in the development of inflammatory bowel
disease (IBD) have reached an important milestone. A decade of genome-wide association …
disease (IBD) have reached an important milestone. A decade of genome-wide association …
Exploring host–microbiota interactions in animal models and humans
AD Kostic, MR Howitt, WS Garrett - Genes & development, 2013 - genesdev.cshlp.org
The animal and bacterial kingdoms have coevolved and coadapted in response to environmental
selective pressures over hundreds of millions of years. The meta'omics revolution in …
selective pressures over hundreds of millions of years. The meta'omics revolution in …
[PDF][PDF] Inflammatory bowel disease as a model for translating the microbiome
C Huttenhower, AD Kostic, RJ Xavier - Immunity, 2014 - cell.com
The inflammatory bowel diseases (IBDs) are among the most closely studied chronic inflammatory
disorders that involve environmental, host genetic, and commensal microbial factors. …
disorders that involve environmental, host genetic, and commensal microbial factors. …
The mutational landscape of head and neck squamous cell carcinoma
N Stransky, AM Egloff, AD Tward, AD Kostic… - science, 2011 - science.org
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing …
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing …
[PDF][PDF] The treatment-naive microbiome in new-onset Crohn's disease
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked
to host pathways that implicate an underlying role for aberrant immune responses to …
to host pathways that implicate an underlying role for aberrant immune responses to …
[HTML][HTML] Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses
indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, …
indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, …
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
The tumor microenvironment of colorectal carcinoma is a complex community of genomically
altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each …
altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each …
[PDF][PDF] Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans
According to the hygiene hypothesis, the increasing incidence of autoimmune diseases in
western countries may be explained by changes in early microbial exposure, leading to …
western countries may be explained by changes in early microbial exposure, leading to …
[PDF][PDF] The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes
… Kostic et al. perform a microbiome analysis of type 1 diabetes (T1D), examining the infant
gut microbiome as T1D develops. Microbial metabolic pathways remain remarkably stable …
gut microbiome as T1D develops. Microbial metabolic pathways remain remarkably stable …
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
Objective Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis.
Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-…
Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-…