… PBs (de Brevern et al. 2000) have been used both to describe the 3D protein backbones (de
Brevern 2005) and to perform local structure prediction (de Brevern et al. 2000, 2007, 2002; …

… de Brevern, respectively. His research is centered on detection and characterization of …
de Brevern, trained as a cell biologist, has been a structural bioinformatician for 20 years. As …

Protein structures are valuable tools to understand protein function. Nonetheless, proteins
are often considered as rigid macromolecules while their structures exhibit specific flexibility, …

By using an unsupervised cluster analyzer, we have identified a local structural alphabet
composed of 16 folding patterns of five consecutive C α (“protein blocks”). The dependence that …

… Of note, patient SF was a carrier of a 4 bp deletion in the promoter of Ag-globin gene, as …
this unique CDA might be caused by a de novo mutation in a transcription factor essential for …

Background A number of methods are now available to perform automatic assignment of
periodic secondary structures from atomic coordinates, based on different characteristics of the …

Protein structures are valuable tools for understanding protein function. However, protein
dynamics is also considered a key element in protein function. Therefore, in addition to …

… The abundance of each gene in a sample was then normalized by dividing the number of
reads that mapped to the gene (A g ) by the gene nucleotide length and by the total number of …

… How to cite this article: de Brevern, AG Extension of the classical classification of β-turns.
Sci… & de Brevern, AG Use of a structural alphabet for analysis of short loops connecting …

Background Microarray technologies produced large amount of data. The hierarchical
clustering is commonly used to identify clusters of co-expressed genes. However, microarray …