[HTML][HTML] Novel genetic loci associated with hippocampal volume

…, L Athanasiu, T Axelsson, AH Beecham… - Nature …, 2017 - nature.com
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

Novel genetic loci underlying human intracranial volume identified through genome-wide association

…, S Seshadri, S Desrivières, AH Beecham… - Nature …, 2016 - nature.com
Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

…, MK Ikram, HH Adams, AH Beecham… - Circulation …, 2015 - Am Heart Assoc
Background— The burden of cerebral white matter hyperintensities (WMH) is associated
with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their …

[PDF][PDF] Low-frequency and rare-coding variation contributes to multiple sclerosis risk

M Mitrovič, NA Patsopoulos, AH Beecham… - Cell, 2018 - cell.com
Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable
to common genetic variants, including >230 identified by genome-wide association …

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

…, P Shoostari, C Cotsapas, G Wong, AH Beecham… - BioRxiv, 2017 - biorxiv.org
We assembled and analyzed genetic data of 47,351 multiple sclerosis (MS) subjects and
68,284 control subjects and establish a reference map of the genetic architecture of MS that …

An ImmunoChip study of multiple sclerosis risk in African Americans

…, JM Moré, PA Gourraud, JL McCauley, AH Beecham… - Brain, 2015 - academic.oup.com
The aims of this study were: (i) to determine to what degree multiple sclerosis-associated
loci discovered in European populations also influence susceptibility in African Americans; (ii) …

[HTML][HTML] GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis

JP Hussman, AH Beecham, M Schmidt, ER Martin… - Genes & …, 2016 - nature.com
To identify genes and biologically relevant pathways associated with risk to develop
multiple sclerosis (MS), the Genome-Wide Association Studies noise reduction method (GWAS-NR) …

Factors associated with failed retrieval of the Günther Tulip inferior vena cava filter

JS Marquess, CT Burke, AH Beecham… - Journal of Vascular and …, 2008 - Elsevier
PURPOSE: To identify potential factors associated with failed retrieval of the Günther Tulip
inferior vena cava (IVC) filter. MATERIALS AND METHODS: A retrospective review was …

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

…, D Ames, GB Boncoraglio, JC Hopewell, AH Beecham… - Neurology, 2019 - AAN Enterprises
Objective To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in
large population-based cohorts. Methods We performed meta-analyses of genome-wide …

Properties of global‐and local‐ancestry adjustments in genetic association tests in admixed populations

…, SH Slifer, AH Beecham, GW Beecham - Genetic …, 2018 - Wiley Online Library
Population substructure can lead to confounding in tests for genetic association, and failure
to adjust properly can result in spurious findings. Here we address this issue of confounding …