10.7554/eLife.27574.001 The temporal regulation of protein abundance and post-translational
modifications is a key feature of cell division. Recently, we analysed gene expression and …

We present a methodology using in vivo crosslinking combined with HPLC-MS for the global
analysis of endogenous protein complexes by protein correlation profiling. Formaldehyde …

Effective network analysis of protein data requires high-quality proteomic datasets. Here, we
report a near doubling in coverage of the C. elegans adult proteome, identifying >11,000 …

Starvation causes comprehensive metabolic changes, which are still not fully understood.
Here, we used quantitative proteomics and RNA sequencing to examine the temporal …

… comparison between human induced and embryonic stem cells Brenes Murillo, Alejandr …
Marchingo JM, Sinclair LV, Howden AJ, Cantrell D. A (2020) Quantitative analysis of how …

Asymmetric cell divisions are required for cellular diversity and defects can lead to altered
daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in …

High-throughput, shotgun proteomics, using data dependent acquisition (DDA), now
enables the comprehensive study of proteomes, allowing the identification of 10,000 or more …

Comprehensive proteome analysis of rare cell phenotypes remains a significant challenge.
We report a method for low cell number MS-based proteomics using protease digestion of …

Cell cycle progression relies on coordinated changes in the composition and subcellular
localization of the proteome. By applying two distinct convolutional neural networks on images …

Membrane-associated proteins are required for essential processes like transport, organelle
biogenesis, and signaling. Many are expected to function as part of an oligomeric protein …