Several non-invasive imaging techniques are used to investigate the effect of pathologies
and treatments over time in mouse models. Each preclinical in vivo technique provides …

Cortical layer-dependent high (sub-millimeter) resolution functional magnetic resonance
imaging (fMRI) in human or animal brain can be used to address questions regarding the …

Cell-based therapy exploits modified human cells to treat diseases but its targeted application
in specific tissues, particularly those lying deep in the body where direct injection is not …

Modern neuroimaging techniques rely on neurovascular coupling to show regions of increased
brain activation. However, little is known of the neurovascular coupling relationships that …

Despite recent advances in alternative brain imaging technologies, functional magnetic
resonance imaging (fMRI) remains the workhorse for both medical diagnosis and primary …

The spatial resolution of hemodynamic-based neuroimaging techniques, including functional
magnetic resonance imaging, is limited by the degree to which neurons regulate their …

Hyperpolarisation methods that premagnetise agents such as pyruvate are currently receiving
significant attention because they produce sensitivity gains that allow disease tracking …

Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their
underlying neurovascular origins have recently gained considerable interest. In this study …

The human SOD1 G93A transgenic mouse has been used extensively since its development
in 1994 as a model for amyotrophic lateral sclerosis (ALS). In that time, a great many …

Functional magnetic resonance imaging (fMRI) signal variations are based on a combination
of changes in cerebral blood flow (CBF) and volume (CBV), and blood oxygenation. We …