Noonan syndrome, the most common single-gene cause of congenital heart disease, is
characterized by short stature, characteristic facies, learning problems and leukemia …

Drug-induced liver injury is a major reason for drug candidate attrition from development,
denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. …

Gene expression is regulated at multiple levels, including transcription and translation, as
well as mRNA and protein stability. Although systems-level functions of transcription factors …

… direct PPARo-binding proximal to all 29 of these PPARo signature genes (Tamburino …
direct NRF2-binding proximal to the majority of the NRF2þNRF1 signature genes (Tamburino …

In response to infection or immunization, antibodies are produced that provide protection
against re-exposure with the same pathogen. These antibodies can persist at high titers for …

Gene expression is controlled through the binding of transcription factors (TFs) to regulatory
genomic regions. First introns are longer than other introns in multiple eukaryotic species …

Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced
liver injury, but is poorly predicted by preclinical animal models. Here we present the …

Background— There is a conflicting evidence on safety and efficacy of transcatheter aortic
valve implantation in patients with preoperative chronic kidney disease (CKD). Therefore, we …

Interactions between RNA binding proteins (RBPs) and mRNAs are critical to post-transcriptional
gene regulation. Eukaryotic genomes encode thousands of mRNAs and hundreds of …

Background— There is a lack of information on the incidence and predictors of early mortality
at 30 days and late mortality between 30 days and 1 year after transcatheter aortic valve …