Background The genome of the domestic cow, Bos taurus, was sequenced using a mixture
of hierarchical and whole-genome shotgun sequencing methods. Results We have …

Motivation: Second-generation sequencing technologies produce high coverage of the
genome by short reads at a low cost, which has prompted development of new assembly …

Here the Human Pangenome Reference Consortium presents a first draft of the human
pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of …

In this paper, we introduce a new, local formulation of the ensemble Kalman filter approach
for atmospheric data assimilation. Our scheme is based on the hypothesis that, when the …

RNA sequencing using the latest single-molecule sequencing instruments produces reads
that are thousands of nucleotides long. The ability to assemble these long reads can greatly …

Aegilops tauschii is the diploid progenitor of the D genome of hexaploid wheat 1 (Triticum
aestivum, genomes AABBDD) and an important genetic resource for wheat 2 , 3 , 4 . The large …

Background The size and complexity of conifer genomes has, until now, prevented full genome
sequencing and assembly. The large research community and economic importance of …

A synergistic combination of two next-generation sequencing platforms with a detailed
comparative BAC physical contig map provided a cost-effective assembly of the genome …

Long sequencing reads generated by single-molecule sequencing technology offer the
possibility of dramatically improving the contiguity of genome assemblies. The biggest challenge …

The current human reference genome, GRCh38, represents over 20 years of effort to generate
a high-quality assembly, which has benefitted society 1 , 2 . However, it still has many …