User profiles for A. W. Reinke
 | Aaron W. ReinkeAssociate professor, University of Toronto, Department of Molecular Genetics Verified email at utoronto.ca Cited by 2695 |
Design of protein-interaction specificity gives selective bZIP-binding peptides
G Grigoryan, AW Reinke, AE Keating - Nature, 2009 - nature.com
Interaction specificity is a required feature of biological networks and a necessary characteristic
of protein or small-molecule reagents and therapeutics. The ability to alter or inhibit …
of protein or small-molecule reagents and therapeutics. The ability to alter or inhibit …
A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering
AW Reinke, RA Grant, AE Keating - Journal of the American …, 2010 - ACS Publications
The versatile coiled-coil protein motif is widely used to induce and control macromolecular
interactions in biology and materials science. Yet the types of interaction patterns that can be …
interactions in biology and materials science. Yet the types of interaction patterns that can be …
Networks of bZIP protein-protein interactions diversified over a billion years of evolution
AW Reinke, J Baek, O Ashenberg, AE Keating - Science, 2013 - science.org
Differences in biomolecular sequence and function underlie dramatic ranges of appearance
and behavior among species. We studied the basic region-leucine zipper (bZIP) …
and behavior among species. We studied the basic region-leucine zipper (bZIP) …
A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions
Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded family …
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded family …
Combinatorial bZIP dimers display complex DNA-binding specificity landscapes
10.7554/eLife.19272.001 How transcription factor dimerization impacts DNA-binding
specificity is poorly understood. Guided by protein dimerization properties, we examined DNA …
specificity is poorly understood. Guided by protein dimerization properties, we examined DNA …
[HTML][HTML] Evolution of microsporidia: An extremely successful group of eukaryotic intracellular parasites
L Wadi, AW Reinke - PLoS pathogens, 2020 - journals.plos.org
Microsporidia are obligate intracellular parasites that can infect a wide range of hosts. They
cause death and disease in both humans and agriculturally important animals. They have …
cause death and disease in both humans and agriculturally important animals. They have …
bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans
The eukaryotic basic leucine zipper (bZIP) transcription factors play critical roles in the
organismal response to the environment. Recently, a novel YAP-like bZIP, restorer of secondary …
organismal response to the environment. Recently, a novel YAP-like bZIP, restorer of secondary …
[HTML][HTML] Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins
Pathogens use a variety of secreted and surface proteins to interact with and manipulate their
hosts, but a systematic approach for identifying such proteins has been lacking. To identify …
hosts, but a systematic approach for identifying such proteins has been lacking. To identify …
The ins and outs of host‐microsporidia interactions during invasion, proliferation and exit
H Tamim El Jarkass, AW Reinke - Cellular Microbiology, 2020 - Wiley Online Library
Microsporidia are a large group of fungal‐related obligate intracellular parasites. They are
responsible for infections in humans as well as in agriculturally and environmentally important …
responsible for infections in humans as well as in agriculturally and environmentally important …
Generation of a microsporidia species attribute database and analysis of the extensive ecological and phenotypic diversity of microsporidia
Microsporidia are a large group of fungus-related obligate intracellular parasites. Though
many microsporidia species have been identified over the past 160 years, depiction of the full …
many microsporidia species have been identified over the past 160 years, depiction of the full …