User profiles for A. Abdellaoui

Abdel Abdellaoui

Department of Psychiatry, Amsterdam UMC, University of Amsterdam
Verified email at amsterdamumc.nl
Cited by 19228

[PDF][PDF] 15 years of GWAS discovery: realizing the promise

A Abdellaoui, L Yengo, KJH Verweij… - The American Journal of …, 2023 - cell.com
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Dissecting polygenic signals from genome-wide association studies on human behaviour

A Abdellaoui, KJH Verweij - Nature Human Behaviour, 2021 - nature.com
Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues. …

Electronic structure and magnetic properties of quaternary Heusler alloys CoRhMnZ (Z= Al, Ga, Ge and Si) via first-principle calculations

M Benkabou, H Rached, A Abdellaoui… - Journal of Alloys and …, 2015 - Elsevier
First-principle calculations are performed to predict the electronic structure and elastic and
magnetic properties of CoRhMnZ (Z = Al, Ga, Ge and Si) Heusler alloys. The calculations …

Genome-wide association study identifies 74 loci associated with educational attainment

…, K Thom, P Timshel, R De Vlaming, A Abdellaoui… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

…, M Trzaskowski, EM Byrne, A Abdellaoui… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

…, NW Martin, HJ Westra, K Shakhbazov, A Abdellaoui… - science, 2013 - science.org
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

…, MA Fontana, M Lebreton, SP Tino, A Abdellaoui… - Nature …, 2019 - nature.com
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

…, G Bjornsdottir, CA Rietveld, A Abdellaoui… - Nature …, 2015 - nature.com
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would
predict creativity. Higher scores were associated with artistic society membership or creative …

Heritability and genomics of gene expression in peripheral blood

…, R Jansen, W Chung, YH Zhou, A Abdellaoui… - Nature …, 2014 - nature.com
We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify
expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most …

Seventy-five genetic loci influencing the human red blood cell

…, HJ Westra, J Yang, J Hua Zhao, F Anni, A Abdellaoui… - Nature, 2012 - nature.com
Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …