The OncoArray Consortium: a network for understanding the genetic architecture of common cancers

…, L Ottini, RJ Hung, J Marchini, A Amin Al Olama… - … , biomarkers & prevention, 2017 - AACR
Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types

SP Kar, J Beesley, A Amin Al Olama, K Michailidou… - Cancer discovery, 2016 - AACR
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic
basis, but this has not been investigated systematically by genome-wide association (GWA) …

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

A Amin Al Olama, T Dadaev, DJ Hazelett… - Human molecular …, 2015 - academic.oup.com
Genome-wide association studies (GWAS) have identified numerous common prostate
cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the …

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations

…, MT Landi, N Caporaso, A Risch, A Amin Al Olama… - Cancer research, 2016 - AACR
Identifying genetic variants with pleiotropic associations can uncover common pathways
influencing multiple cancers. We took a two-stage approach to conduct genome-wide …

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

A Amin Al Olama, Z Kote-Jarai… - Human molecular …, 2013 - academic.oup.com
Genome-wide association studies (GWAS) have identified multiple common genetic variants
associated with an increased risk of prostate cancer (PrCa), but these explain less than one-…

Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study

…, BE Henderson, A Amin Al Olama… - Human molecular …, 2015 - academic.oup.com
Epidemiological studies have reported inconsistent associations between telomere length (TL)
and risk for various cancers. These inconsistencies are likely attributable, in part, to …

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

…, D Thompson, A Amin Al Olama… - Human molecular …, 2013 - academic.oup.com
Mean telomere length (TL) in blood cells is heritable and has been reported to be associated
with risks of several diseases, including cancer. We conducted a meta-analysis of three …

[HTML][HTML] Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis

…, P Harrington, S Benlloch, A Amin Al Olama… - Genetics in …, 2015 - nature.com
Purpose: This study aimed to quantify the probability of overdiagnosis of prostate cancer by
polygenic risk. Methods: We calculated the polygenic risk score based on 66 known prostate …

[HTML][HTML] Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript

Z Kote-Jarai, A Amin Al Olama, D Leongamornlert… - Human genetics, 2011 - Springer
Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa)
susceptibility loci. One of these (rs2735839) is located close to a plausible candidate …

Simple MRI score aids prediction of dementia in cerebral small vessel disease

A Amin Al Olama, JMS Wason, AM Tuladhar… - Neurology, 2020 - AAN Enterprises
Objective To determine whether a simple small vessel disease (SVD) score, which uses
information available on rapid visual assessment of clinical MRI scans, predicts risk of cognitive …