The localization of mRNAs to subcellular compartments provides a mechanism for regulating
gene expression with exquisite temporal and spatial control. Recent studies suggest that a …

10.7554/eLife.03058.001 Although a small number of the vast array of animal long non-coding
RNAs (lncRNAs) have known effects on cellular processes examined in vitro, the extent …

As highlighted by recent genome-wide analyses in diverse organisms and cell types,
subcellular targeting of mRNAs has emerged as a major mechanism for cells to establish …

oskar is one of seven Drosophila maternal-effect genes that are necessary for germline and
abdomen formation. We have cloned oskar and show that oskar RNA is localized to the …

The mouse heavy chain immunoglobulin gene contains a tissue-specific enhancer. The
enhancer and flanking sequences were studied in vivo by carrying out dimethyl sulfate …

The oskar gene directs germ plasm assembly and controls the number of germ cell precursors
formed at the posterior pole of the Drosophila embryo. Mislocalization of oskar RNA to the …

oskar messenger RNA localization at the posterior pole of the Drosophila oocyte is essential
for germline and abdomen formation in the future embryo 1 , 2 . The nuclear shuttling …

Morphogenesis and cell differentiation in multicellular organisms often require accurate
control of cell divisions. We show that a novel cell cycle regulator, tribbles, is critical for this …

Analysis of single molecules in living cells has provided quantitative insights into the
kinetics of fundamental biological processes; however, the dynamics of messenger RNA (mRNA) …

Differentiation of the embryonic termini in Drosophiladepends on signaling by the Tor RTK,
which induces terminal gene expression by inactivating at the embryonic poles a uniformly …