The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal structure. …

Extracting biologically meaningful information from chromosomal interactions obtained with
genome-wide chromosome conformation capture (3C) analyses requires the elimination of …

Topologically associating domains (TADs) are fundamental structural and functional building
blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain …

Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Hematopoietic stem cells (HSCs) sustain long-term reconstitution of hematopoiesis in
transplantation recipients, yet their role in the endogenous steady-state hematopoiesis remains …

During cell division, chromosomes are compacted in length by more than a 100-fold. A wide
range of experiments demonstrated that in their compacted state, mammalian chromosomes …

Effect of strain rate and its discontinuous changes on the deformation and microstructural
behavior of a coarse-grained 7475 Al alloy were studied in multidirectional forging at 763K. …

Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …

… of Anton Goloborodko is supported by the Austrian Academy of Sciences. Anton Goloborodko
is … The authors thank all the members of the Goloborodko lab for productive discussions. …

10.7554/eLife.14864.001 The mechanism by which chromatids and chromosomes are
segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using …