User profiles for A. Hattersley

Professor Andrew Hattersley

University of Exeter
Verified email at exeter.ac.uk
Cited by 147671

The fetal insulin hypothesis: an alternative explanation of the association of low bir thweight with diabetes and vascular disease

AT Hattersley, JE Tooke - The Lancet, 1999 - thelancet.com
Low birthweight is associated with insulin resistance, hypertension, coronary-artery disease,
and non-insulin-dependent diabetes (NIDDM). A suggested explanation for this association …

The clinical utility of C‐peptide measurement in the care of patients with diabetes

AG Jones, AT Hattersley - Diabetic medicine, 2013 - Wiley Online Library
C‐peptide is produced in equal amounts to insulin and is the best measure of endogenous
insulin secretion in patients with diabetes. Measurement of insulin secretion using C‐peptide …

[PDF][PDF] Definition, epidemiology and classification of diabetes in children and adolescents

ME Craig, A Hattersley, KC Donaghue - Pediatr diabetes, 2009 - academia.edu
This article is a chapter in the ISPAD Clinical Practice Consensus Guidelines 2009 Compendium.
The complete set of guidelines can be found at www. ispad. org. The evidence grading …

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

…, M Gross, Y Guo, S Hackinger, S Han, AT Hattersley… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

…, BO Boehm, H Campbell, MJ Daly, AT Hattersley… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

…, O Pedersen, NJ Wareham, I Barroso, AT Hattersley… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

…, AD Morris, ASF Doney, MI McCarthy, AT Hattersley - Science, 2007 - science.org
The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

…, AD Morris, PJ Donnelly, TM Frayling, AT Hattersley… - Nature …, 2012 - nature.com
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

…, H Nishigori, J Takeda, SS Fajans, AT Hattersley… - Nature, 1996 - nature.com
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin 1 . It affects …

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

…, TM Frayling, V Giedraitis, S Hackinger, AT Hattersley… - Nature …, 2018 - nature.com
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …