The functional state of a cell is largely determined by the spatiotemporal organization of its
proteome. Technologies exist for measuring particular aspects of protein turnover and …

The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm.
The inner nuclear membrane (INM) functions in essential nuclear processes including …

With the wide access to studies of selected gene expressions in transgenic animals, mice
have become the dominant species as cerebral disease models. Many of these studies are …

The directed migration of cell collectives is a driving force of embryogenesis 1 , 2 , 3 . The
predominant view in the field is that cells in embryos navigate along pre-patterned …

Spindle elongation in anaphase of mitosis is a cell cycle–regulated process that requires
coordination between polymerization, cross-linking, and sliding of microtubules (MTs). Proteins …

Longitudinal studies on brain pathology and assessment of therapeutic strategies rely on a
fully mature adult brain to exclude confounds of cerebral developmental changes. Thus, …

INTRODUCTION Whole-genome duplication (WGD) events are pervasive in eukaryotes,
shaping the genomes of simple single-celled organisms, such as yeast, as well as those of …

The metaphase-to-anaphase transition is one of the most dramatic and highly regulated
steps in cell division. At anaphase onset the protease separase dissolves sister chromatid …

10.7554/eLife.45506.001 Tail-anchored (TA) proteins insert post-translationally into the
endoplasmic reticulum (ER), the outer mitochondrial membrane (OMM) and peroxisomes. …

The yeast Saccharomyces cerevisiae is ideal for systematic studies relying on collections of
modified strains (libraries). Despite the significance of yeast libraries and the immense …