The goal of cancer immunotherapy is to boost a patient's immune response to a tumour. Yet,
the design of an effective immunotherapy is complicated by various factors, including a …

1α,25-Dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] regulates calcium homeostasis and controls
cellular differentiation and proliferation. The vitamin D receptor (VDR) is a ligand-regulated …

The combination of SCD1 inhibitors and ferroptosis inducers may provide a new therapeutic
strategy for the treatment of ovarian cancer patients. See related commentary by Carbone …

The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1…

Hepcidin is a peptide hormone that negatively regulates iron efflux and plays an important
role in controlling the growth of breast tumors. In patients with breast cancer, the combined …

The exact mechanisms of spontaneous tumor remission or complete response to treatment
are phenomena in oncology that are not completely understood. We use a concept from …

Ovarian cancer (OC) has an overall modest number of mutations that facilitate a functional
immune infiltrate able to recognize tumor mutated antigens, or neoantigens. Although patient-…

Ferroptosis is a recently discovered form of iron-dependent regulated cell death (RCD) that
occurs via peroxidation of phospholipids containing polyunsaturated fatty acid (PUFA) …

The tumor microenvironment is an integral component in promoting tumor development.
Cancer-associated fibroblasts (CAFs), which reside in the tumor stroma, produce Hepatocyte …

We develop a three-dimensional multispecies mathematical model to simulate the growth of
colon cancer organoids containing stem, progenitor and terminally differentiated cells, as a …