User profiles for A. Kriegstein

Arnold Kriegstein

Verified email at ucsf.edu
Cited by 53214

The glial nature of embryonic and adult neural stem cells

A Kriegstein, A Alvarez-Buylla - Annual review of neuroscience, 2009 - annualreviews.org
Glial cells were long considered end products of neural differentiation, specialized supportive
cells with an origin very different from that of neurons. New studies have shown that some …

Is there more to GABA than synaptic inhibition?

DF Owens, AR Kriegstein - Nature Reviews Neuroscience, 2002 - nature.com
In the mature brain, GABA (γ-aminobutyric acid) functions primarily as an inhibitory
neurotransmitter. But it can also act as a trophic factor during nervous system development to …

[HTML][HTML] Development and evolution of the human neocortex

JH Lui, DV Hansen, AR Kriegstein - Cell, 2011 - cell.com
The size and surface area of the mammalian brain are thought to be critical determinants of
intellectual ability. Recent studies show that development of the gyrated human neocortex …

The human cell atlas

…, M Hemberg, S Kim, P Klenerman, A Kriegstein… - elife, 2017 - elifesciences.org
10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …

Neurons derived from radial glial cells establish radial units in neocortex

…, TA Weissman, RS Dammerman, AR Kriegstein - Nature, 2001 - nature.com
The neocortex of the adult brain consists of neurons and glia that are generated by precursor
cells of the embryonic ventricular zone. In general, glia are generated after neurons during …

Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

…, V Martínez-Cerdeño, L Ivic, AR Kriegstein - Nature …, 2004 - nature.com
Precise patterns of cell division and migration are crucial to transform the neuroepithelium
of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal …

Glutamate neurotoxicity in cortical cell culture

…, M Maulucci-Gedde, AR Kriegstein - Journal of …, 1987 - Soc Neuroscience
The central neurotoxicity of the excitatory amino acid neurotransmitter glutamate has been
postulated to participate in the pathogenesis of the neuronal cell loss associated with several …

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

…, KI Auguste, EF Chang, AJ Gutierrez, AR Kriegstein… - Nature, 2018 - nature.com
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the
adult mammalian hippocampus 1 , 2 , 3 , 4 , 5 . This process has been linked to learning and …

Neurogenic radial glia in the outer subventricular zone of human neocortex

DV Hansen, JH Lui, PRL Parker, AR Kriegstein - Nature, 2010 - nature.com
Neurons in the developing rodent cortex are generated from radial glial cells that function
as neural stem cells. These epithelial cells line the cerebral ventricles and generate …

GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis

…, DF Owens, MJS Heath, MBE Davis, AR Kriegstein - Neuron, 1995 - cell.com
We have found that, during the early stages of cortical neurogenesis, both GABA and glutamate
depolarize cells in the ventricular zone of rat embryonic neocortex. In the ventricular zone…