[HTML][HTML] OPTN/SRTR 2018 annual data report: liver
Data on adult liver transplants performed in the US in 2018 are notable for (1) continued
growth in numbers of new waitlist registrants (11,844) and transplants performed (8250); (2) …
growth in numbers of new waitlist registrants (11,844) and transplants performed (8250); (2) …
Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus
AD Kwong, RS Kauffman, P Hurter, P Mueller - Nature biotechnology, 2011 - nature.com
Infection with hepatitis C virus (HCV) is a major medical problem with over 170 million
people infected worldwide. Substantial morbidity and mortality are associated with hepatic …
people infected worldwide. Substantial morbidity and mortality are associated with hepatic …
[HTML][HTML] Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and collaborative
drug discovery efforts took place in academia and industry, culminating in several …
drug discovery efforts took place in academia and industry, culminating in several …
Next-generation genotype imputation service and methods
Genotype imputation is a key component of genetic association studies, where it increases
power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is …
power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is …
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer
Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 -…
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 -…
[HTML][HTML] Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
…, L McNair, S George, T Kieffer, A Kwong… - … England Journal of …, 2009 - Mass Medical Soc
Background In patients with chronic infection with hepatitis C virus (HCV) genotype 1, treatment
with peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic …
with peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic …
[HTML][HTML] Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records
…, TC Yang, CF Huggins, ASF Kwong… - Nature …, 2022 - nature.com
The frequency of, and risk factors for, long COVID are unclear among community-based
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …
Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts
BackgroundThe COVID-19 pandemic and mitigation measures are likely to have a marked
effect on mental health. It is important to use longitudinal data to improve inferences.AimsTo …
effect on mental health. It is important to use longitudinal data to improve inferences.AimsTo …
Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer after moderately emetogenic …
…, KJ Horgan, F Skobieranda, A Kwong - Journal of Clinical …, 2005 - hub.hku.hk
PURPOSE: This is the first study in which the NK(1)-receptor antagonist, aprepitant (APR),
was evaluated for the prevention of chemotherapy-induced nausea and vomiting (CINV) with …
was evaluated for the prevention of chemotherapy-induced nausea and vomiting (CINV) with …
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
Background & Aims: Telaprevir (VX-950), a hepatitis C virus (HCV) NS3·4A protease inhibitor,
has shown strong antiviral activity in phase 1 clinical studies. Because of high levels of …
has shown strong antiviral activity in phase 1 clinical studies. Because of high levels of …