User profiles for A. Lazar

Alexander J. Lazar MD/PhD

Professor; Pathology, Genomic Medicine, Dermatology & Transl Molec Pathol, MD Anderson …
Verified email at mdanderson.org
Cited by 123801

Biochemistry of the para-sulfonato-calix [n] arenes

F Perret, AN Lazar, AW Coleman - Chemical Communications, 2006 - pubs.rsc.org
The biochemistry of the para-sulfonato-calix[n]arenes has shown rapid development during
the past ten years, the highly diverse biomedical applications of these molecules now …

[HTML][HTML] The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms

…, H Kimura, W Klapper, AE Kovach, S Kumar, AJ Lazar… - Leukemia, 2022 - nature.com
We herein present an overview of the upcoming 5 th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

Circulating tumor DNA analysis in patients with cancer: American Society of Clinical Oncology and College of American Pathologists joint review

…, M Diehn, P Hurley, AJ Lazar… - … of pathology & …, 2018 - meridian.allenpress.com
Purpose.— Clinical use of analytical tests to assess genomic variants in circulating tumor
DNA (ctDNA) is increasing. This joint review from the American Society of Clinical Oncology …

Biopharmaceutical applications of calixarenes

E Da Silva, AN Lazar, AW Coleman - Journal of Drug Delivery Science and …, 2004 - Elsevier
During the last 15 years, water soluble calixarenes and especially para-sulphonato-calix[n]arene
and amphiphilic calixarenes have been the subject of growing interest in the biological …

Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

S Mourtas, AN Lazar, E Markoutsa… - European journal of …, 2014 - Elsevier
With the objective to formulate multifunctional nanosized liposomes to target amyloid deposits
in Alzheimer Disease (AD) brains, a lipid–PEG–curcumin derivative was synthesized and …

[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics

…, T Lichtenberg, KA Hoadley, LM Poisson, AJ Lazar… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …

Melanoma staging: evidence‐based changes in the American Joint Committee on Cancer eighth edition cancer staging manual

…, GV Long, MI Ross, AJ Lazar… - CA: a cancer journal …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE To update the melanoma staging system of the
American Joint Committee on Cancer (AJCC) a large database was assembled comprising >…

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

…, EM Burton, JM Gardner, E Sirmans, J Hu, AJ Lazar… - Science, 2018 - science.org
Preclinical mouse models suggest that the gut microbiome modulates tumor response to
checkpoint blockade immunotherapy; however, this has not been well-characterized in human …

Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: possible applications to Alzheimer disease

AN Lazar, S Mourtas, I Youssef, C Parizot… - … , Biology and Medicine, 2013 - Elsevier
Accumulation of amyloid peptide (Aβ) in senile plaques is a hallmark lesion of Alzheimer
disease (AD). The design of molecules able to target the amyloid pathology in tissue is …

[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer

KA Hoadley, C Yau, T Hinoue, DM Wolf, AJ Lazar… - Cell, 2018 - cell.com
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …