Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

…, P Paulo, A Brandão, S Watya, A Lubwama… - Nature …, 2021 - nature.com
Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …

The contribution of rare variation to prostate cancer heritability

…, L Le Marchand, A Lubwama… - Nature …, 2016 - nature.com
We report targeted sequencing of 63 known prostate cancer risk regions in a multi-ancestry
study of 9,237 men and use the data to explore the contribution of low-frequency variation to …

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

…, P Paulo, A Brandão, S Watya, A Lubwama… - Nature …, 2023 - nature.com
The transferability and clinical value of genetic risk scores (GRSs) across populations remain
limited due to an imbalance in genetic studies across ancestrally diverse populations. Here …

Prostate cancer susceptibility in men of African ancestry at 8q24

…, JS Witte, G Casey, A Lubwama… - Journal of the …, 2016 - academic.oup.com
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate
cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8–128.8Mb) in …

Two novel susceptibility loci for prostate cancer in men of African ancestry

…, AJM Hennis, Y Han, A Lubwama… - JNCI: Journal of the …, 2017 - academic.oup.com
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations.
The risk factors that drive this disparity are unknown and potentially consist of social, …

Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry

…, JH Fowke, G Casey, AJ Hennis, A Lubwama… - European urology, 2023 - Elsevier
Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of African …

[HTML][HTML] A germline variant at 8q24 contributes to familial clustering of prostate cancer in men of African ancestry

…, P Blanchet, G Casey, AJM Hennis, A Lubwama… - European urology, 2020 - Elsevier
Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or
mutations have been identified that contribute to familial clustering of PCa in this population. We …

Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk

…, L Le Marchand, S Kaggwa, A Lubwama… - Human molecular …, 2016 - academic.oup.com
Prostate cancer is the most common non-skin cancer in males, with a ∼1.5–2-fold higher
incidence in African American men when compared with whites. Epidemiologic evidence …

[HTML][HTML] A rare germline HOXB13 variant contributes to risk of prostate cancer in men of African ancestry

…, P Blanchet, G Casey, AJM Hennis, A Lubwama… - European urology, 2022 - Elsevier
A rare African ancestry–specific germline deletion variant in HOXB13 (X285K, rs77179853)
was recently reported in Martinican men with early-onset prostate cancer. Given the role of …

[HTML][HTML] Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk …

…, P Paulo, A Brandão, S Watya, A Lubwama… - Nature …, 2021 - nature.com
In the version of this article originally published, the names of the equally contributing authors
and jointly supervising authors were switched. The correct affiliations are:“These authors …