Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
The contribution of rare variation to prostate cancer heritability
…, L Le Marchand, A Lubwama… - Nature …, 2016 - nature.com
We report targeted sequencing of 63 known prostate cancer risk regions in a multi-ancestry
study of 9,237 men and use the data to explore the contribution of low-frequency variation to …
study of 9,237 men and use the data to explore the contribution of low-frequency variation to …
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain
limited due to an imbalance in genetic studies across ancestrally diverse populations. Here …
limited due to an imbalance in genetic studies across ancestrally diverse populations. Here …
Prostate cancer susceptibility in men of African ancestry at 8q24
…, JS Witte, G Casey, A Lubwama… - Journal of the …, 2016 - academic.oup.com
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate
cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8–128.8Mb) in …
cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8–128.8Mb) in …
Two novel susceptibility loci for prostate cancer in men of African ancestry
…, AJM Hennis, Y Han, A Lubwama… - JNCI: Journal of the …, 2017 - academic.oup.com
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations.
The risk factors that drive this disparity are unknown and potentially consist of social, …
The risk factors that drive this disparity are unknown and potentially consist of social, …
Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry
…, JH Fowke, G Casey, AJ Hennis, A Lubwama… - European urology, 2023 - Elsevier
Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of African …
Objective To discover common genetic variants contributing to the risk of PCa in men of African …
[HTML][HTML] A germline variant at 8q24 contributes to familial clustering of prostate cancer in men of African ancestry
…, P Blanchet, G Casey, AJM Hennis, A Lubwama… - European urology, 2020 - Elsevier
Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or
mutations have been identified that contribute to familial clustering of PCa in this population. We …
mutations have been identified that contribute to familial clustering of PCa in this population. We …
Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk
…, L Le Marchand, S Kaggwa, A Lubwama… - Human molecular …, 2016 - academic.oup.com
Prostate cancer is the most common non-skin cancer in males, with a ∼1.5–2-fold higher
incidence in African American men when compared with whites. Epidemiologic evidence …
incidence in African American men when compared with whites. Epidemiologic evidence …
[HTML][HTML] A rare germline HOXB13 variant contributes to risk of prostate cancer in men of African ancestry
…, P Blanchet, G Casey, AJM Hennis, A Lubwama… - European urology, 2022 - Elsevier
A rare African ancestry–specific germline deletion variant in HOXB13 (X285K, rs77179853)
was recently reported in Martinican men with early-onset prostate cancer. Given the role of …
was recently reported in Martinican men with early-onset prostate cancer. Given the role of …
[HTML][HTML] Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk …
…, P Paulo, A Brandão, S Watya, A Lubwama… - Nature …, 2021 - nature.com
In the version of this article originally published, the names of the equally contributing authors
and jointly supervising authors were switched. The correct affiliations are:“These authors …
and jointly supervising authors were switched. The correct affiliations are:“These authors …