Gene silencing through RNA interference (RNAi) has revolutionized the study of gene function,
particularly in non-model insects. However, in Lepidoptera (moths and butterflies) RNAi …

The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the
maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner and …

1 Nature America, Inc. All rights reserv ed. perspective 514 volume 43| number 6| june 2011|
NATURE GENETICS region if a similar association was found in this population, as the …

Background Spectral‐domain optical coherence tomography has been used in several
neurological conditions, and peripapillary and macular measurements have been proposed as …

The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment
of variant pathogenicity for multiple cancer syndrome genes. Independent data types …

Mutations in BRCA1 are present in 45% of families that segregate with susceptibility for
breast cancer and in 80–90% of families with both breast and ovarian cancer. Here we report …

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are a promising class of targeted
cancer drugs, but their individual target profiles beyond the PARP family, which could result in …

Many sequence variants in predisposition genes are of uncertain clinical significance, and
classification of these variants into high- or low-risk categories is an important problem in …

Region‐growing segmentation algorithms are useful for remote sensing image segmentation.
These algorithms need the user to supply control parameters, which control the quality of …

As genetic testing for predisposition to human diseases has become an increasingly
common practice in medicine, the need for clear interpretation of the test results is apparent. …