User profiles for A. Murumagi
Astrid MurumagiSenior Scientist, FIMM, Helsinki University Verified email at helsinki.fi Cited by 973 |
Haematological health state indices of reproducing great tits: methodology and sources of natural variation
I Ots, A Murumägi, P Horak - Functional Ecology, 1998 - Wiley Online Library
1. A cornerstone concept of ecological immunology is that immune function, interacting with
various aspects of individual health state, plays a central role in the life‐history trade‐offs …
various aspects of individual health state, plays a central role in the life‐history trade‐offs …
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
…, MM Majumder, JML Marti, P Mattila, A Murumägi… - Cancer discovery, 2013 - AACR
We present an individualized systems medicine (ISM) approach to optimize cancer drug
therapies one patient at a time. ISM is based on (i) molecular profiling and ex vivo drug …
therapies one patient at a time. ISM is based on (i) molecular profiling and ex vivo drug …
[HTML][HTML] Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1
…, K Visvalingam, P Peterson, K Möll, A Murumägi… - PLoS …, 2006 - journals.plos.org
Background The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction.
In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive …
In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive …
[HTML][HTML] Identification of fusion genes in breast cancer by paired-end RNA-sequencing
H Edgren, A Murumagi, S Kangaspeska, D Nicorici… - Genome biology, 2011 - Springer
Background Until recently, chromosomal translocations and fusion genes have been an
underappreciated class of mutations in solid tumors. Next-generation sequencing technologies …
underappreciated class of mutations in solid tumors. Next-generation sequencing technologies …
[HTML][HTML] Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
…, MM Majumder, D Malani, A Murumägi… - Scientific reports, 2014 - nature.com
We developed a systematic algorithmic solution for quantitative drug sensitivity scoring (DSS),
based on continuous modeling and integration of multiple dose-response relationships in …
based on continuous modeling and integration of multiple dose-response relationships in …
Colorectal cancer consensus molecular subtypes translated to preclinical models uncover potentially targetable cancer cell dependencies
…, PW Eide, IA Eilertsen, L Ramirez, A Murumägi… - Clinical Cancer …, 2018 - AACR
Purpose: Response to standard oncologic treatment is limited in colorectal cancer. The
gene expression–based consensus molecular subtypes (CMS) provide a new paradigm for …
gene expression–based consensus molecular subtypes (CMS) provide a new paradigm for …
FusionCatcher–a tool for finding somatic fusion genes in paired-end RNA-sequencing data
…, M Şatalan, H Edgren, S Kangaspeska, A Murumägi… - biorxiv, 2014 - biorxiv.org
FusionCatcher is a software tool for finding somatic fusion genes in paired-end RNA-sequencing
data from human or other vertebrates. FusionCatcher achieves competitive detection …
data from human or other vertebrates. FusionCatcher achieves competitive detection …
Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes
…, A Meager, L Tserel, T Org, A Murumägi… - Blood, The Journal …, 2008 - ashpublications.org
Neutralizing autoantibodies to type I, but not type II, interferons (IFNs) are found at high titers
in almost every patient with autoimmune polyendocrinopathy candidiasis ectodermal …
in almost every patient with autoimmune polyendocrinopathy candidiasis ectodermal …
Targeting ROR1 identifies new treatment strategies in hematological cancers
H Karvonen, W Niininen, A Murumägi… - Biochemical Society …, 2017 - portlandpress.com
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR receptor
family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. …
family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. …
Consistency in drug response profiling
The comparative analysis by Haibe-Kains et al. 1 concluded that data from two large-scale
studies of cancer cell lines 2, 3 showed highly discordant results for drug sensitivity …
studies of cancer cell lines 2, 3 showed highly discordant results for drug sensitivity …