Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs
and link them to cellular membranes. They integrate cellular architectural and signalling …

Filamins are elongated homodimeric proteins that crosslink F-actin. Each monomer chain of
filamin comprises an actin-binding domain, and a rod segment consisting of six (…

The social amoebae are exceptional in their ability to alternate between unicellular and
multicellular forms. Here we describe the genome of the best-studied member of this group, …

Nesprins form a novel class of nuclear envelope-anchored spectrin-repeat proteins. We show
that a direct association of their highly conserved C-terminal luminal domain with the inner …

The LIM domain is an evolutionary conserved double-zinc finger motif found in a variety of
proteins exhibiting diverse biological roles. LIM domains have been observed to act as …

A gene trap-type targeting vector was designed to inactivate the beta 1 integrin gene in
embryonic stem (ES) cells. Using this vector more than 50% of the ES cell clones acquired a …

Dictyostelium discoideum (DD), an extensively studied model organism for cell and developmental
biology, belongs to the most derived group 4 of social amoebas, a clade of altruistic …

Giant isoforms, encoded by Nesprin-1 (Syne1) and Nesprin-2 (Syne2), are multifunctional
actin-binding and nuclear-envelope-associated proteins belonging to the spectrin superfamily. …

Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13–p12 cause
a late-onset form of autosomal dominant inclusion body myopathy associated with Paget …

We generated Dictyostelium double mutants lacking the two F-actin crosslinking proteins α-actinin
and gelation factor by inactivating the corresponding genes via homologous …