User profiles for A. Ruzo

Albert Ruzo

- Verified email at dfci.harvard.edu - Cited by 3249

Andrés A. Ruzo

- Verified email at smu.edu - Cited by 276

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

G Mullokandov, A Baccarini, A Ruzo, AD Jayaprakash… - Nature …, 2012 - nature.com
We introduce two large-scale resources for functional analysis of microRNA (miRNA): a decoy
library for inhibiting miRNA function and a sensor library for monitoring microRNA activity. …

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

…, H Takizawa, H Salmon, J Idoyaga, A Ruzo… - Journal of Experimental …, 2014 - rupress.org
Langerhans cell histiocytosis (LCH) is a clonal disorder with elusive etiology, characterized
by the accumulation of CD207 + dendritic cells (DCs) in inflammatory lesions. Recurrent …

[PDF][PDF] Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

…, X Sanchez, S McCarthy, J Schaller, Z Khan, A Ruzo… - Cell, 2022 - cell.com
Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but
patients relapse, highlighting the need to understand the mechanisms of resistance. We …

[HTML][HTML] Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy

…, S Marcó, A Ribera, M Garcia, A Ruzo… - The Journal of …, 2013 - Am Soc Clin Investig
For most lysosomal storage diseases (LSDs) affecting the CNS, there is currently no cure.
The BBB, which limits the bioavailability of drugs administered systemically, and the short half-…

Temperature-at-depth maps for the conterminous US and geothermal resource estimates

D Blackwell, M Richards, Z Frone, J Batir, A Ruzo… - 2011 - osti.gov
A third generation geothermal resource assessment has recently been completed for the
conterminous US based on a revised heat flow map using over 35,000 data sites. …

Self-organization of human embryonic stem cells on micropatterns

…, F Etoc, MC Guerra, I Martyn, J Metzger, A Ruzo… - Nature …, 2016 - nature.com
Fate allocation in the gastrulating embryo is spatially organized as cells differentiate into
specialized cell types depending on their positions with respect to the body axes. There is a …

The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

J Agudo, A Ruzo, N Tung, H Salmon, M Leboeuf… - Nature …, 2014 - nature.com
miR-126 is a microRNA expressed predominately by endothelial cells and controls
angiogenesis. We found miR-126 was required for the innate response to pathogen-associated …

[PDF][PDF] A balance between secreted inhibitors and edge sensing controls gastruloid self-organization

F Etoc, J Metzger, A Ruzo, C Kirst, A Yoney, MZ Ozair… - Developmental cell, 2016 - cell.com
The earliest aspects of human embryogenesis remain mysterious. To model patterning events
in the human embryo, we used colonies of human embryonic stem cells (hESCs) grown …

Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer

A Ruzo, S Marcó, M García, P Villacampa… - Human gene …, 2012 - liebertpub.com
Mucopolysaccharidosis type IIIA (MPSIIIA) is a rare lysosomal storage disorder caused by
mutations in the sulfamidase gene. Accumulation of glycosaminoglycan (GAG) inside the …

Self-organization of a human organizer by combined Wnt and Nodal signalling

I Martyn, TY Kanno, A Ruzo, ED Siggia, AH Brivanlou - Nature, 2018 - nature.com
In amniotes, the development of the primitive streak and its accompanying ‘organizer’ define
the first stages of gastrulation. Although these structures have been characterized in detail …