Current gaps in sepsis immunology: new opportunities for translational research
…, MG Netea, T van der Poll, A Scherag… - The Lancet infectious …, 2019 - thelancet.com
Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group …
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group …
[HTML][HTML] Gene–environment interactions for complex traits: definitions, methodological requirements and challenges
A Dempfle, A Scherag, R Hein, L Beckmann… - European Journal of …, 2008 - nature.com
Genetic and environmental risk factors and their interactions contribute to the development
of complex diseases. In this review, we discuss methodological issues involved in …
of complex diseases. In this review, we discuss methodological issues involved in …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Defining the role of common variation in the genomic and biological architecture of adult human height
…, R Mägi, E Mihailov, E Porcu, JC Randall, A Scherag… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …
significance that together explained one-fifth of the heritability for adult height. By testing …
New genetic loci link adipose and insulin biology to body fat distribution
…, T Fall, Z Kutalik, J Luan, JC Randall, A Scherag… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
[HTML][HTML] Cefazolin versus anti-staphylococcal penicillins for the treatment of patients with Staphylococcus aureus bacteraemia
Background For patients with bacteraemia caused by methicillin-sensitive Staphylococcus
aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice. While ASPs …
aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice. While ASPs …
Common variants near MC4R are associated with fat mass, weight and risk of obesity
…, NW Rayner, SM Ring, MS Sandhu, A Scherag… - Nature …, 2008 - nature.com
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
…, TJ Iwashyna, FM Brunkhorst, TD Rea, A Scherag… - Jama, 2016 - jamanetwork.com
Importance The Third International Consensus Definitions Task Force defined sepsis as “life-threatening
organ dysfunction due to a dysregulated host response to infection.” The …
organ dysfunction due to a dysregulated host response to infection.” The …
Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations
C Fleischmann, A Scherag, NKJ Adhikari… - American journal of …, 2016 - atsjournals.org
Rationale: Reducing the global burden of sepsis, a recognized global health challenge,
requires comprehensive data on the incidence and mortality on a global scale. Objectives: To …
requires comprehensive data on the incidence and mortality on a global scale. Objectives: To …
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
…, F Rybakowski, P Santonastaso, A Scherag… - Nature …, 2019 - nature.com
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …